Bendamustine Hydrochloride CAS: 3543-75-7
MF: C16H21Cl2N3O2•HCl
MW: 394.72
A nitrogen mustard purine analog alkylator.

Bendamustine Hydrochloride (CAS 3543-75-7)

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Alternativa namn: 5-[Bis(2-chloroethyl)-amino]-1-methyl-1H-benzimidazole-2-butanoic Acid Hydrochloride;Ribomustin HCl; Treanda HCl; SDX-105 HCl; 1H-Benzimidazole-2-butanoic acid; 5-[bis(2-chloroethyl)amino]-1-methyl monohydrochloride
Ansökan Bendamustine Hydrochloride is a nitrogen mustard purine analog alkylator
CAS Nr: 3543-75-7
Molekylvikt: 394.72
Molekylär formel: C16H21Cl2N3O2•HCl
Kompletterande information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Bendamustine Hydrochloride is a small molecule bifunctional DNA alkylating agent, combining a nitrogen mustard functionality with a purine-analog structure. The dense DNA-damaging functionality of Bendamustine differentiates it from other compounds used as antiproliferative agents, and these functionalities are thought to promote cell death through a variety of different pathways including apoptosis and mitotic catastrophe. Accordingly it has been indicated for use in treating proliferations and malignancies refractory to the effects of other DNA alkylators. Efficacy against chronic lymphocytic leukemia is particularly indicated with Bendamustine, presenting a potential intervention upon this notoriously variable and ubiquitous type of malignancy.


Konferenser

1. Balfour, J.A. and Goa, K.L. 2001. Drugs. 61: 631-639. PMID: 11368287
2. Schwänen, C., et al. 2002. Leukemia. 16: 2096-2105. PMID: 12357363
3. Wendtner, C.M., et al. 2004. Semin. Hematol. 41: 224-233. PMID: 15269882
4. Keating, M.J., et al. 2008. Nat Rev Drug Discov. 7: 473-474. PMID: 18511926

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in methanol, DMSO (≥79 mg/ml) at 25° C, water (≥15 mg/ml) at 25° C, and ethanol (≥17 mg/ml) at 25° C.
LAGRING :
Store at -20° C
Melting Point :
149-151°C
Boiling Point :
585.2° C at 760 mmHg (Predicted)
IC50 :
SU-DHL-1 cell proliferation: IC50 = 50 µM
pK Values :
pKa: 4.50, pKb: 7.24
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
DE1590000
PubChem CID :
Merck Index :
14: 1032
MDL Number :
MFCD01658758
Beilstein Registry :
6031568
SMILES :
CN1C2=C(C=C(C=C2)N(CCCl)CCCl)N=C1CCCC(=O)O.Cl

Download SDS (MSDS)

Certificate of Analysis

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