Benazeprilat CAS: 86541-78-8
MF: C22H24N2O5
MW: 396.44
A potent ACE inhibitor.

Benazeprilat (CAS 86541-78-8)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 134ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Benazeprilat is rated 5.0 out of 5 by 1.
5
1
4
0
3
0
2
0
1
0
Alternativa namn: USP Benazepril Related Compound C
Ansökan Benazeprilat is a potent ACE inhibitor
CAS Nr: 86541-78-8
Molekylvikt: 396.44
Molekylär formel: C22H24N2O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Benazeprilat is the active metabolite of benazepril (sc-337551), formed after cleavage of the ester group. Benazeprilat is a potent inhibitor of angiotensin-converting enzyme (ACE). This prevents the conversion of angiotensin I to the vasoconstrictor angiotensin II.


Konferenser

1. Kitagawa, Hitoshi., et al., 2003. An angiotensin converting enzyme inhibitor, benazepril can be transformed to an active metabolite, benazeprilat, by the liver of dogs with ascitic pulmonary heartworm disease. The Journal of veterinary medical science / the Japanese Society of Veterinary Science. 65(6): 701-6. PMID: 12867730
2. Toutain, P L., et al., 2004. Pharmacokinetics and pharmacokinetic/pharmacodynamic relationships for angiotensin-converting enzyme inhibitors. Journal of veterinary pharmacology and therapeutics. 27(6): 515-25. PMID: 15601445
3. Wang, Xue-Ding., et al., 2007. Simultaneous and rapid quantitation of benazepril and benazeprilat in human plasma by high performance liquid chromatography with ultraviolet detection. Journal of pharmaceutical and biomedical analysis. 44(1): 224-30. PMID: 17289327

Physical State :
Solid
Solubility :
Soluble in DMSO.
LAGRING :
Store at -20° C
Melting Point :
254-256° C
Boiling Point :
~711.3° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.64 (Predicted)
Optical Activity :
α20/D -200.5°, c = 1 in 3% aqueous NH4OH
IC50 :
Angiotensin-converting enzyme: IC50 = 1.7 nM (European rabbit)
pK Values :
pKa: 2.17 (Predicted), pKb: 8.35 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
MFCD08060091
SMILES :
C1CC2=CC=CC=C2N(C(=O)[[email protected]]1N[[email protected]@H](CCC3=CC=CC=C3)C(=O)O)CC(=O)O

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Benazeprilat (CAS 86541-78-8)  Produkt Citat

See how others have used Benazeprilat (CAS 86541-78-8). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 24863555  2014. J Pharm Biomed Anal. 98: 1-8.

Citations 1 to 1 of 1 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 135ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 6ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2021 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.