Ascomycin CAS: 104987-12-4
MF: C43H69NO12
MW: 792.01
Ascomycin is a potent immunosuppressive agent.

Ascomycin (CAS 104987-12-4)

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Ansökan Ascomycin is a potent immunosuppressive agent
CAS Nr: 104987-12-4
Molekylvikt: 792.01
Molekylär formel: C43H69NO12
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ascomycin is a potent immunosuppressive agent that could be used as a potential therapeutic agent for autoimmune diseases. Ascomycin is an inhibitor of PP2.


Konferenser

Matuszewski, B., et al.: Anal. Chem., 75, 3019 (2003), Taylor, P., et al.: Clin. Chem., 51, 1890(2005),

Physical State :
Solid
Solubility :
Soluble in DMSO (65 mg/ml), ethanol (50 mg/ml), and water (10-50 µM).
LAGRING :
Store at -20° C
Melting Point :
156-160° C
Boiling Point :
868° C
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.55 (Predicted)
IC50 :
Inhibition of human mixed lymphocyte proliferation : IC50 = 0.25 nM; Inhibition of human mixed lymphocyte response : IC50 = 0.25 nM; Allogenic T-lymphocyte activation : IC50 = 0.26 nM; Calcineurin phosphatase: IC50 = 49 nM (human); Peptidyl-prolyl cis-trans isomerase and chaperone activities of PfFKBP35: IC50 = 0.52 µM
pK Values :
pKa: 9.97 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
KD4185000
PubChem CID :
MDL Number :
MFCD06198665

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Certificate of Analysis

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