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Arachidonylcyclopropylamide (ACPA) is an analog of N-arachidonylethanolamine and a selective agonist of the CB1 (cannabinoid receptor1) (Ki = 2.2 nM). The compound has displayed marked selectivity for the CB1 receptor over the CB2 receptor by 325 fold. ACPA is described to inhibit forskolin-induced accumulation of cAMP in hamster ovary cells, and to increase cerebellar membrane binding of [35S]GTPγS. APCA is also described to produce a dose-dependent increase in microglial BV-2 cell migration. Agonism of the CB1 receptor by ACPA shows effects on GABAergic inhibitory neurotransmission, demonstrating an inhibition of GABAergic synaptic transmission onto superficial and deep medial entorhinal neurons.
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See how others have used Arachidonylcyclopropylamide (ACPA). Click on the entry to view the PubMed entry .
PMID: # 19506935 Huerta, M. et al. 2009. J. Membr. Biol. 229: 91-99.
PMID: # 18322861 Jafari, MR. et al. 2008. Int. J. Neurosci. 118: 531-543.
PMID: # 18797248 Zarrindast, MR. et al. 2008. Behav Pharmacol. 19: 716-723.
PMID: # 17595216 Herling, AW. et al. 2007. Am. J. Physiol. Endocrinol. Metab. 293: E826-E832.
PMID: # 11828716 Hayase, T. et al. 2001. Nihon Arukoru Yakubutsu Igakkai Zasshi. 36: 596-608.
PMID: # 10336536 Hillard, CJ. et al. 1999. J. Pharmacol. Exp. Ther. 289: 1427-1433.
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