α-Dystrobrevin Antibody (B-1) is a mouse monoclonal IgM (kappa light chain) provided at 200 µg/ml
specific for an epitope mapping between amino acids 351-371 within an internal region of α-Dystrobrevin of human origin
recommended for detection of all isoforms of α-Dystrobrevin of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for α-Dystrobrevin Antibody (B-1). This work is in progress.
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Labware ships FedEx Ground free of charge to the contiguous US
Dystrobrevins are protein components of the dystrophin complex, whose disruption leads to Duchenne muscular dystrophy and related diseases. α-dystrobrevin is a dystrophin-related and -associated protein that is involved in synapse maturation and is required for normal muscle function. α-Dystrobrevin is a component of the dystrophin glycoprotein complex. It is localized to the cytoplasmic side of the sarcolemma and is highly concentrated at the neuromuscular junctions in skeletal muscle. The insertion of 57 amino acids by alternative splicing accounts for the increase in molecular mass of α-Dystrobrevin 1 in skeletal and cardiac muscle compared with brain and lung. α-Dystrobrevin containing complexes are found in endothelial and smooth muscle cells, while β-Dystrobrevin containing complexes are present at the basal region of renal epithelial cells. Additionally, β-Dystrobrevin is found in neurons and is highly enriched in postsynaptic densities. Alternative splicing of α-Dystrobrevin produces γ-Dystrobrevin (isoform 5), δ-Dystrobrevin (isoform 7), ε-Dystrobrevin (isoform 6) and ζ-Dystrobrevin (isoform 8). Additional isoforms may also exist.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.