AGL 2043 CAS: 22617-28-8
MF: C15H12N4S
MW: 280.4
A cell permeable compound that acts as a potent inhibitor of type III receptor tyrosine kinases.

AGL 2043 (CAS 22617-28-8)

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AGL 2043 is rated 5.0 out of 5 by 1.
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Ansökan AGL 2043 is a cell permeable compound that acts as a potent inhibitor of type III receptor tyrosine kinases
Momsregistreringsnummer :: 22617-28-8
Molecular Weight: 280.4
Molecular Formula: C15H12N4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

AGL 2043 is a cell-permeable, tricyclic quinoxaline compound that acts as a potent, selective, ATP-competitive, and reversible inhibitor of type III receptor tyrosine kinases PDGFR (IC50 = 800 nM in 3T3 cells; 90 nM against purified PDGFβ-receptor), Flt-3/Flk-2 (Flt3), and c-Kit (Kit) (IC50 ~1-3 μM).Weakly inhibits PKA, EGFR, IGF-1R, VEGFR, and Src kinases (IC50 > 30 μM). Potently inhibits smooth muscle cell proliferation and balloon-induced stenosis in porcine heart.


Konferenser

1. Gazit, A., et al. 2003. Bioorg. Med. Chem. 11: 2007-2018. PMID: 12670652

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml).
LAGRING :
Store at 4° C
IC50 :
type III receptor tyrosine kinases PDGFR: IC50 = 800 nM (3T3 cells); purified PDGFβ-receptor: IC50 = 90 nM; Kit: IC50 = 1-3 µM; Src kinases: IC50 = >30 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9817165
SMILES :
CC1=NC2=C(N1C)C=C3C(=C2)N=C(C=N3)C4=CC=CS4

Download SDS (MSDS)

Certificate of Analysis

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