AG 1433 Hydrochloride MF: C16H14N2O2·HCl
MW: 302.76
A PDGF-β receptor kinase and angiogenesis inhibitor.

AG 1433 Hydrochloride

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Alternativa namn: 2-(3,4-Dihydroxyphenyl)-6,7-dimethylquinoxaline
Ansökan AG 1433 Hydrochloride is a PDGF-β receptor kinase and angiogenesis inhibitor
Molecular Weight: 302.76
Molecular Formula: C16H14N2O2·HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

AG 1433 Hydrochloride is a specific and potent inhibitor of platelet-derived growth factor-β receptor kinase (PDGF-β receptor kinase, IC50 = 5.0 μM) and of Flk-1/KDR/VEGF Receptor 2 (IC50 = 9.3 μM). AG 1433 Hydrochloride also acts as angiogenesis inhibitor.


Konferenser

1. Strawn, L M., et al., 1996. Flk-1 as a target for tumor growth inhibition. Cancer research. 56(15): 3540-5. PMID: 8758924
2. Kroll, J., et al., 1997. The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells. The Journal of biological chemistry. 272(51): 32521-7. PMID: 9405464

Physical State :
Solid
Solubility :
DMSO (3 mg/ml). Further dilute with aqueous buffers just before use.
LAGRING :
Store at -20° C
Boiling Point :
511.7° C at 760 mmHg (Predicted)
Refractive Index :
n20D ~1.69 (Predicted)
IC50 :
PDGFR-beta: IC50 = 5 µM; Flk-1: IC50 = 9.3 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
MDL Number :
MFCD03490489

Download SDS (MSDS)

Certificate of Analysis

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