Ac-DEVD-AFC CAS: 201608-14-2
MF: C30H34F3N5O13
MW: 729.61

Ac-DEVD-AFC (CAS 201608-14-2)

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Alternativa namn: Ac-DEVD-AFC is also known as Caspase-3 Substrate (Fluorogenic).
Ansökan Ac-DEVD-AFC is a fluorogenic substrate for caspase-3 and related cysteine proteases, used as an indicator for cellular caspase-3 effects.
CAS Nr: 201608-14-2
Renhet: ≥90%
Molekylvikt: 729.61
Molekylär formel: C30H34F3N5O13
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ac-DEVD-AFC is a fluorogenic substrate for caspase-3 (CPP32) and related cysteine proteases, which emits a blue to green shift in fluorescence. It also acts as a substrate for granzyme B-processed caspase-6, caspase-7, caspase-8, and caspase-10. It is known that Ac-DEVD-AFC has a greater Stokes′ shift than Ac-DEVD-AMC once it has been cleaved. Since caspase-3 is an effector caspase, it is involved in the cleavage of many substrates which promote apoptosis. This indicator excites light at 400 nm and emits light at 505 nm. In addition, Ac-DEVD-AFC is modeled after Asp216 on caspase-3, the PARP cleavage site. Ac-DEVD-AFC is an essential indicator used to monitor the cellular effects of caspase-3.


Konferenser

1. Lazebnik, Y.A., et al. 1994. Nature. 371: 346-347. PMID: 8090205

2. Nicholson, D.W., et al. 1995. Nature 376: 37-43. PMID: 7596430

3. Xiang, J., et al. 1996. Proc. Natl. Acad. Sci. U.S.A. 93: 14559-14563. PMID: 896209

4 .Chandler, J.M., et al. 1998. J. Biol. Chem. 273: 10815-10818. PMID: 9556551

5. Marcelli, M., et al. 1998. Cancer Res. 58: 76-83. PMID: 9426061

Appearance :
Powder
Physical State :
Solid
Sequence :
Ac-Asp-Glu-Val-Asp-AFC
Solubility :
Soluble in 50% acetic acid in water (5 mg/ml), DMF, DMSO, methanol, and slightly soluble water (0.4 mg/ml).
LAGRING :
Store at -20° C
Boiling Point :
~1152.7° C at 760 mmHg (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.57 (Predicted)
Fluoresence :
λex 400 nm, λem 505 nm
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD01310970
SMILES :
CC(C)[[email protected]@H](C(=O)N[[email protected]@H](CC(=O)O)C(=O)NC1=CC2=C(C=C1)C(=CC(=O)O2)C(F)(F)F)NC(=O)[[email protected]](CCC(=O)O)NC(=O)[[email protected]](CC(=O)O)NC(=O)C

Download SDS (MSDS)

Certificate of Analysis

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Ac-DEVD-AFC (CAS 201608-14-2)  Produkt Citat

See how others have used Ac-DEVD-AFC (CAS 201608-14-2). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 12 total

PMID: # 31131063  2019. Theranostics. 9: 2712-2726.

PMID: # 30589566  Xu, X.|Pan, J.|Li, H.|Li, X.|Fang, F.|Wu, D.|Zhou, Y.|Zheng, P.|Xiong, L.|Zhang, D.| et al. 2018. FASEB J. fj201801515R.

PMID: # 28340475  Erdem, ZN. et al. 2017. Transl Oncol. 10: 332-339.

PMID: # 28708069  2017. Int J Mol Sci. 18:

PMID: # 28981087  van Raam, BJ. et al. 2017. Cell Death Dis. 8: e3069.

PMID: # 27220334  Means, JC. et al. 2016. Neurochem. Res.

PMID: # 23303820  van Kruchten, R. et al. 2013. Blood. 121: 1850-7.

PMID: # 32492146  Toxicol Sci. 446-459.

PMID: # 33324059  Neuropsychiatr Dis Treat. 2975-2987.

PMID: # 31919747  Cell. Mol. Neurobiol.

Citations 1 to 10 of 12 total
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