4-Hydroxyphenylretinamide CAS: 65646-68-6
MF: C26H33NO2
MW: 391.55
An agonist displaying activity at retinoid receptors.

4-Hydroxyphenylretinamide (CAS 65646-68-6)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 133ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: Retinoic acid p-hydroxyanilide; Fenretinide; 4-HPR
Ansökan An agonist displaying activity at retinoid receptors
Momsregistreringsnummer :: 65646-68-6
Molecular Weight: 391.55
Molecular Formula: C26H33NO2
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

4-Hydroxyphenylretinamide (Fenretinide) is a synthetic retinoid analog of all trans retinoic acid, which displays antiproliferative effects on cultured human breast cancer cells. In addition, 4-Hydroxyphenylretinamide functions as a selective activator of RAR (retinoid receptors). Studies involving lymphoid and myeloid malignant cell lines indicate that 4-Hydroxyphenylretinamide can induce apoptosis and reduce cell growth. These studies suggest that 4-Hydroxyphenylretinamide and all trans retanoic acid may bind to two different receptors to induce apoptosis.


Konferenser

1. Marth, C., et al. 1985. J. Natl. Cancer Inst. 75: 871-875. PMID: 2932587
2. Grubbs, C.J., et al. 1990. Anticancer Res. 10: 661-666. PMID: 2142393
3. Delia, D., et al. 1993. Cancer Res. 53: 6036-6041. PMID: 8261419
4. Ponzoni, M., et al. 1995. Cancer Res. 55: 853-861. PMID: 7850799
5. Fanjul, A.N., et al. 1996. J. Biol. Chem. 271: 22441-22446. PMID: 8798408

Physical State :
Solid
Solubility :
Soluble in DMSO (25 mg/ml), ethanol (25 mg/ml)), chloroform, and acetone (easily soluble).
LAGRING :
Store at -20° C
Refractive Index :
n20D 1.61
IC50 :
MDA-MB-231 (Breast adenocarcinoma cells): IC50 = 7700 (human); MCF7 (Breast carcinoma cells): IC50 = 150 (human); PC-3 (Prostate carcinoma cells): IC50 = 3600 (human); LNCaP (Prostate carcinoma): IC50 = 7500 (human)
Ki Data :
Retinoic acid receptor gamma: Ki= >400 nM (human); Retinoid X receptor alpha: Ki= >2200 nM (human); Retinoid X receptor beta: Ki= >2800 nM (human); Retinoid X receptor gamma: Ki= >6000 nM (human)
pK Values :
pKa: 9.98, pKb: 1.55
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
VH6420000
PubChem CID :
5288209
Merck Index :
14: 3998
MDL Number :
MFCD00792674
SMILES :
CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)NC2=CC=C(C=C2)O)C)C

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 170ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 27ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.