2-Imino-4-methylpiperidine acetate is a potent, general NOS inhibitor. 2-Imino-4-methylpiperidine exhibits IC50 values of 0.1, 1.1, and 0.2 μM for inhibition of human NOS2 (iNOS), NOS3 (eNOS), and NOS1 (nNOS), respectively, at an arginine concentration of 30 μM.
Webber, R.K., Metz, S., Moore, W.M., et al. Substituted 2-iminopiperidines as inhibitors of human nitric oxide synthase isoforms. J Med Chem 41 96-101 (1998).