13-cis-Retinoic acid CAS: 4759-48-2
MF: C20H28O2
MW: 300.44
A vitamin A analog that inhibits cell proliferation.

13-cis-Retinoic acid (CAS 4759-48-2)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 120ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
13-cis-Retinoic acid is rated 5.0 out of 5 by 1.
5
1
4
0
3
0
2
0
1
0
Alternativa namn: Isotretinoin; Accutane; Amnesteem; Claravis
Ansökan 13-cis-Retinoic acid is a vitamin A analog that inhibits cell proliferation
CAS Nr: 4759-48-2
Renhet: ≥98%
Molekylvikt: 300.44
Molekylär formel: C20H28O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

13-cis-Retinoic acid is a vitamin A analog that inhibits cell proliferation and induces cell differentiation. Clinically, 13-cis-Retinoic acid is primarily used in the treatment of severe recalcitrant nodular acne. Its effects include reducing the production of sebum, shrinking the size of the sebaceous glands, stabilizing keratinization, preventing comedones from forming, and reducing inflammation of inflammatory acne. Though the exact mechanism of action of 13-cis-Retinoic acid is not fully understood, studies have suggested that the compound alters DNA transcription and induces apoptosis in select types of cells throughout the body.


Konferenser

1. Samokyszyn, V.M., et al. 1987. J. Biol. Chem. 262: 14119-14133. PMID: 3115987
2. Samokyszyn, V.M., et al. 1997. Chem. Res. Toxicol. 10: 795-801. PMID: 9250414
3. Chang, H.C., et al. 2000. Kaohsiung J. Med. Sci. 16: 387-392. PMID: 11221542

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in chloroform (50 mg/ml), DMSO (60 mg/ml at 25° C), water (<1 mg/ml at 25° C), ethanol (25 mg/ml), and ether (sparingly).
LAGRING :
Store at -20° C
Melting Point :
172-175° C (lit.)
Boiling Point :
~462.80° C at 760 mmHg (Predicted)
Density :
1.01 g/cm3 (Predicted)
Refractive Index :
n20D 1.56 (Predicted)
IC50 :
ERK 2: IC50 = 0.46 µM (human); SR-2B: IC50 = 0.85 µM (human); Cellular retinoic acid-binding protein I: IC50 = 0.9 µM (red junglefowl); Retinoic acid receptor α: IC50 >1 µM (mouse); Retinoic acid receptor γ: IC50 >1 µM (mouse)
Ki Data :
SR-2B: Ki= 0.54 µM (human); Adenosine A3-R: Ki= 2.36 µM (human); α2B-AR: Ki= 3.02 µM (human); Dictyostelium discoideum AX2 RNase P: Ki= 20 µM
pK Values :
pKa: 4.76 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
VH6440000
PubChem CID :
Merck Index :
14: 5228
MDL Number :
MFCD00079542
EC Number :
225-296-0
Beilstein Registry :
1885770
SMILES :
CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C\\C(=O)O)/C)/C

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

13-cis-Retinoic acid (CAS 4759-48-2)  Produkt Citat

See how others have used 13-cis-Retinoic acid (CAS 4759-48-2). Click on the entry to view the PubMed entry .

Citations 1 to 7 of 7 total

PMID: # 10955779  Dahl, AR. et al. 2000. Clin. Cancer Res. 6: 3015-3024.

PMID: # 10550153  Ayoub, J. et al. 1999. J. Clin. Oncol. 17: 3546-3552.

PMID: # 1734084  Lippman, SM. et al. 1992. J. Natl. Cancer Inst. 84: 235-241.

PMID: # 2764704  Klug, S. et al. 1989. Arch. Toxicol. 63: 185-192.

PMID: # 3278754  Koeffler, HP. et al. 1988. Blood. 71: 703-708.

PMID: # 6219631  Leyden, JJ. et al. 1982. Arch. Dermatol. Res. 272: 331-337.

PMID: # 6930601  Shklar, G. et al. 1980. Oral Surg. Oral Med. Oral Pathol. 50: 45-52.

Citations 1 to 7 of 7 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 103ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 7ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2021 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.