Date published: 2025-12-4

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2,3-Dihydroxybenzaldehyde (CAS 24677-78-9)

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CAS Number:
24677-78-9
Molecular Weight:
138.12
Molecular Formula:
C7H6O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2,3-Dihydroxybenzaldehyde is an antifungal and antimicrobial agent. In one study, 2,3-dihydroxybenzaldehyde was identified as a potent chemosensitizing agent that targets the cell wall. Furthermore, an additional study confirmed that 2,3-dihydroxybenzaldehyde disrupted the MAPK pathway via the SOD2 gene. The same study also found that when used with other antifungal agents such as fludioxonil, it prevented fungal mutants from developing tolerance to fludioxonil. Also found to be useful in synthesis of Amberlite XAD resins that can be used to preconcentrate metals from soil samples.


2,3-Dihydroxybenzaldehyde (CAS 24677-78-9) References

  1. Chemosensitization of fungal pathogens to antimicrobial agents using benzo analogs.  |  Kim, JH., et al. 2008. FEMS Microbiol Lett. 281: 64-72. PMID: 18284447
  2. Chemosensitization prevents tolerance of Aspergillus fumigatus to antimycotic drugs.  |  Kim, J., et al. 2008. Biochem Biophys Res Commun. 372: 266-71. PMID: 18486603
  3. Determination of trace heavy metals in soil and sediments by atomic spectrometry following preconcentration with Schiff bases on Amberlite XAD-4.  |  Kara, D., et al. 2009. J Hazard Mater. 165: 1165-9. PMID: 19070432
  4. Inhibition of phosphatidylinositol kinase by toyocamycin.  |  Nishioka, H., et al. 1990. J Antibiot (Tokyo). 43: 1586-9. PMID: 2177464
  5. Synthesis of benzophenonehydrazone Schiff bases and their in vitro antiglycating activities.  |  Khan, KM., et al. 2013. Med Chem. 9: 588-95. PMID: 23151265
  6. A selective naked-eye chemosensor derived from 2-methoxybenzylamine and 2,3-dihydroxybenzaldehyde - synthesis, spectral characterization and electrochemistry of its bis-bidentates Schiff bases metal complexes.  |  Djouhra, A., et al. 2017. Spectrochim Acta A Mol Biomol Spectrosc. 184: 299-307. PMID: 28525865
  7. Gentisaldehyde and Its Derivative 2,3-Dihydroxybenzaldehyde Show Antimicrobial Activities Against Bovine Mastitis Staphylococcus aureus.  |  Schabauer, A., et al. 2018. Front Vet Sci. 5: 148. PMID: 30050910
  8. Formation of Phenolic Compounds from d-Galacturonic Acid.  |  Urbisch, A., et al. 2018. J Agric Food Chem. 66: 11407-11413. PMID: 30295036
  9. Template Synthesis, Spectral, Thermal and Glucose Sensing of Pr3+ Complexes of Metformin Schiff-Bases.  |  Mahmoud, M., et al. 2019. J Fluoresc. 29: 319-333. PMID: 30652231
  10. Synthesis, Structural, and Physicochemical Characterization of a Ti6 and a Unique Type of Zr6 Oxo Clusters Bearing an Electron-Rich Unsymmetrical {OON} Catecholate/Oxime Ligand and Exhibiting Metalloaromaticity.  |  Passadis, SS., et al. 2020. Inorg Chem. 59: 18345-18357. PMID: 33289378
  11. Assembly of pinwheel/twist-shaped chiral lanthanide clusters with rotor structures by an annular/linear growth mechanism and their magnetic properties.  |  Long, BF., et al. 2022. Dalton Trans. 51: 17040-17049. PMID: 36305364
  12. Breaking and Formation of Intramolecular Hydrogen Bonds in Dihydroxybenzaldehydes through UV-Induced Conformational Changes in a Low-Temperature Matrix.  |  Doddipatla, S., et al. 2022. J Phys Chem A. 126: 8645-8657. PMID: 36373975
  13. Hafnium(IV) Chemistry with Imide-Dioxime and Catecholate-Oxime Ligands: Unique {Hf5} and Metalloaromatic {Hf6}-Oxo Clusters Exhibiting Fluorescence.  |  Passadis, SS., et al. 2022. Inorg Chem. 61: 20253-20267. PMID: 36461927
  14. Anthracene scaffold as highly selective chemosensor for Al3+ and its AIEE activity.  |  Mudi, N., et al. 2023. Photochem Photobiol Sci. 22: 1491-1503. PMID: 36805447

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2,3-Dihydroxybenzaldehyde, 5 g

sc-238279
5 g
$46.00