Zinquin ethyl ester is a lipophilic, zinc-sensitive, cell-permeable fluorescent probe. It can be found in living cells because the ethyl ester is cleaved by cytosolic esterase to give Zinquin that carry a negative charge, preventing its efflux across the plasma membrane.
Correlation of apoptosis with change in intracellular labile Zn(II) using zinquin [(2-methyl-8-p-toluenesulphonamido-6-quinolyloxy)acetic acid], a new specific fluorescent probe for Zn(II): P.D. Zalewski, et al.; Biochem. J. 296, 403 (1993) Flux of intracellular labile zinc during apoptosis (gene-directed cell death) revealed by a specific chemical probe, Zinquin: P.D. Zalewski, et al.; Chem. Biol. 1, 153 (1994) Measurement of zinc in hepatocytes by using a fluorescent probe, zinquin: relationship to metallothionein and intracellular zinc: P. Coyle, et al.; Biochem. J. 303, 781 (1994) Video image analysis of labile zinc in viable pancreatic islet cells using a specific fluorescent probe for zinc: P.D. Zalewski, et al.; J. Histochem. Cytochem. 42, 877 (1994) Intracellular zinc movement and its effect on the carbohydrate metabolism of isolated rat hepatocytes: I.A. Brand & J. Kleineke; J. Biol. Chem. 271, 1941 (1996)
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