Zinpyr-1A cell-permeable fluorescent probe that is selective for Zinc with an Emmax = 515 nm

Zinpyr-1 (CAS 288574-78-7)

Zinpyr-1 | CAS 288574-78-7 is rated 4.5 out of 5 by 2.
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Synonym: 4',5'-Bis[bis(2-pyridylmethyl)aminomethyl]-2',7'-dichlorofluorescein
Application: A cell-permeable fluorescent probe that is selective for Zinc with an Emmax = 527 nm
CAS Number: 288574-78-7
Purity: ≥95%
Molecular Weight: 823.72
Molecular Formula: C46H36Cl2N6O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Zinpyr-1 is a cell-permeable fluorescent probe that is selective for Zinc. Fluorescence: max. Em. λ = 527 nm


References

Koh, J., et al.: Science, 272, 1013 (1996), Suh, S., et al.: Brain Res., 852, 268 (2000), Finney, L., et al.: Science, 300, 931 (2003), Lopantsev, V., et al.: Neuroscience, 116, 237 (2003), Kambe, T., et al.: Cell Mol. Life Sci., 61, 49 (2004),

Physical State :
Solid
Solubility :
Soluble in Dichloromethane, DMSO and Ethanol
Storage :
Store at -20° C
Melting Point :
>185° C (dec.)
Boiling Point :
~931.2° C at 760 mmHg (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
4250764
MDL Number :
MFCD04039712
SMILES :
C1=CC=C(C(=C1)C2=C3C=C(C(=O)C(=C3OC4=C(C(=C(C=C24)Cl)O)CN(CC5=CC=CC=N5)CC6=CC=CC=N6)CN(CC7=CC=CC=N7)CC8=CC=CC=N8)Cl)C(=O)O

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Certificate of Analysis

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Zinpyr-1  Product Citations

See how others have used Zinpyr-1. Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 28621879  Kashyap, DR. et al. 2017. Mol. Microbiol. 105: 755-776.

PMID: # 27271668  Wee, J. et al. 2016. Toxins. 8:

PMID: # 27610572  Singer, M. et al. 2016. Cell. 166: 1500-1511.e9.

PMID: # 25562657  Gilad, D. et al. 2015. Neurobiology of disease. 81: 4-13.

PMID: # 24356796  Figueroa, JA. et al. 2014. Metallomics : integrated biometal science. 6: 301-15.

PMID: # 22318122  Lee, JY. et al. 2012. Journal of neuropathology and experimental neurology. 71: 211-22.

Citations 1 to 6 of 6 total

From this page, the emission maxima of zinpyr-1 is 515 nm. But other articles showed the emission maxima of zinpyr-1 is within 525~530 nm. Do you know articles which shows the emission maxima of zinpyr-1 is 515 nm?

Asked by: Kouhei
Thank you for your question. We have reviewed our product information and are now updating the λem to 527. We can not provide any literature reference for the previously listed 515 nm.
Answered by: Technical Support
Date published: 2019-01-04

I tried dissolving the compound to 2.5 mmol (2.5 ml DMSO and 5 mg material) but cannot get it into solution. Do you have recommendations on DMSO as the solvent?

Asked by: two2igm05
Thank you for your question. ZP-1 is soluble in the organic solvent dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of ZP-1 in DMF is approximately 0.5 mg/ml. ZP-1 is sparingly soluble in aqueous solutions. To enhance aqueous solubility, dilute the organic solvent solution into aqueous buffers or isotonic saline. If performing biological experiments, ensure the residual amount of organic solvent is insignificant, since organic solvents may have physiological effects at low concentrations. We do not recommend storing the aqueous solution for more than one day. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2019-04-17
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Rated 4 out of 5 by from Great features! We bought this a month ago and it works nicely to measure zinc concentration in both mammalian cells and bacteria.
Date published: 2016-12-17
Rated 5 out of 5 by from Radford et al Radford et al. (PubMed ID 25512838) used Zinpyr-1, a zinc-selective reacting-based probe, as a fluorescin-based sensor for peptide-based targeting within living cells. -SCBT Publication Review
Date published: 2015-07-13
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