Zinc chlorideA lewis acid used to catalyze the Fischer Indole synthesis an the Friedel-Crafts acylation reactions

Zinc chloride (CAS 7646-85-7)

Zinc chloride | CAS 7646-85-7 is rated 5.0 out of 5 by 1.
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Synonym: Dichlorozinc
Application: A lewis acid used to catalyze the Fischer Indole synthesis an the Friedel-Crafts acylation reactions
CAS Number: 7646-85-7
Purity: ≥98%
Molecular Weight: 136.30
Molecular Formula: ZnCl2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Zinc chloride is a widely used as a moderate-strength Lewis acid. In biochemistry research this is used for a source of the zinc ion. It can also be used alone or with phenols for preserving railway ties, fireproofing timber, and with ammonium chloride as a flux for soldering and etching of metals.


References

1. Nyffeler, P.T., et al. 2002. J. Am. Chem. Soc. 124: 10773-10778. PMID: 12207533
2. Klein, C., et al. 2002. J. Biol. Chem. 277: 11859-11865. PMID: 11805091

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in water (4320 mg/ml at 25° C), ethanol (slightly), acetone (slightly), ether, and glycerol.
Storage :
Store at room temperature
Melting Point :
293° C (lit.)
Boiling Point :
732° C (lit.)
Density :
2.91 g/cm3 at 20° C
IC50 :
PP2B-Aα: IC50 = 1.10 µM (human); CA II: IC50 = 1.16 µM (human); Fyn: IC50 = 1.88 µM (human); EGFR: IC50 = 2.19 µM (human); Androgen Receptor: IC50 = 6.51 µM (rat)
Ki Data :
Androgen Receptor: Ki= 4.34 µM (rat); SLC6A2: Ki= 6.95 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
ZH1400000
PubChem CID :
5727
Merck Index :
14: 10132
MDL Number :
MFCD00011295
EC Number :
231-592-0
SMILES :
Cl[Zn]Cl

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Various publications cite the use of Zinc Various publications cite the use of Zinc chloride as a moderate-strength Lewis acid. In biochemistry research this is used for a source of the zinc ion. -SCBT Publication Review
Date published: 2015-02-27
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