Zebularine is a cell-permeable chemically stable cytidine analog and DNA methylation inhibitor which acts by forming a covalent complex with DNMT. It displays antiangiogenic activity and markedly inhibits vessel formation in different tumor models. It reactivates silenced E-cadherin and potentiates the effects of other epigenetic therapeutics such as vorinistat. Induces differentiation of mesenchymal cells into cardiomyocytes. Inhibits cytidine deaminase (CDD).
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2. Zhou, L., et al., 2002. Zebularine: a novel DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases. Journal of molecular biology. 321(4): 591-9. PMID: 12206775
3. Cheng, Jonathan C., et al., 2003. Inhibition of DNA methylation and reactivation of silenced genes by zebularine. Journal of the National Cancer Institute. 95(5): 399-409. PMID: 12618505
4. Cheng, Jonathan C., et al., 2004. Preferential response of cancer cells to zebularine. Cancer cell. 6(2): 151-8. PMID: 15324698
See how others have used Zebularine. Click on the entry to view the PubMed entry .
PMID: # 15550378 Peng, B. et al. 2005. J. Biol. Chem. 280: 4182-4187.
PMID: # 14729971 Cheng, J.C. et al. 2004. Mol. Cell. Biol. 24: 1270-1278.
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