Zaragozic acid A trisodium salt A potent inhibitor of squalene synthase

Zaragozic acid A trisodium salt (CAS 144541-82-2)

Zaragozic acid A trisodium salt | CAS 144541-82-2 is rated 5.0 out of 5 by 1.
  • y_2019, m_4, d_23, h_21
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_302001, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 206ms
  • REVIEWS, PRODUCT
Synonym: Squalestatin A; Squalestatin S1; L 694599
Application: A potent inhibitor of squalene synthase
CAS Number: 144541-82-2
Purity: >95%
Molecular Weight: 756.68
Molecular Formula: C35H43Na3O14
* Refer to Certificate of Analysis for lot specific data (including water content).

Zaragozic acid A trisodium salt is a potent inhibitor of mammalian, fungal and Saccharomyces cervisiae squalene synthase. As a squalene synthase inhibitor, zaragozic acid has been shown to produce lower plasma cholesterol levels in primates. We offer also offer the free acid form, Zaragozic Acid A (sc-391058), to avoid stability problems associated with hydrolysis of the salt.


References

Bergstrom, J.D. Proc. Natl. Acad. Sci. U. S. A. 90, 80, (1993) Bergstrom, J.D. Annu. Rev. Microbiol. 49, 607, (1995) Kennedy, M.A. Biochim. Biophys. Acta 1445, 110, (1999) Petras, S.F., et al. J. Lipid Res. 40, 24, (1999)

Physical State :
Solid
Solubility :
Soluble in ethanol (10 mg/ml), and DMSO (10 mg/ml, heating may be required).
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
6438355
Merck Index :
14: 10114
MDL Number :
MFCD03788025
SMILES :
CC[C@H](C)C[C@H](C)/C=C/C(=O)O[C@@H]1[C@H]([C@]2(O[C@@H]([C@]([C@@]1(O2)C(=O)O)(C(=O)O)O)C(=O)O)CCC(=C)[C@H]([C@H](C)CC3=CC=CC=C3)OC(=O)C)O

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 89ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Liu Liu, CI. et al. (PubMed 22474324) determined the structure of Zaragozic acid A (ZA-A), a potent inhibitor, in vivo and in vitro, of mammalian, fungal and Saccharomyces cervisiae squalene synthase (SQS), complexed with human SQS. ZA-A binding induces a local conformational change in the substrate binding site, and its C-6 acyl group also extends over to the cofactor binding cavity. -SCBT Publication Review
Date published: 2015-04-15
  • y_2019, m_4, d_23, h_21
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_302001, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 75ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.