Zaragozic acid A trisodium salt is a potent inhibitor of mammalian, fungal and Saccharomyces cervisiae squalene synthase. As a squalene synthase inhibitor, zaragozic acid has been shown to produce lower plasma cholesterol levels in primates. We offer also offer the free acid form, Zaragozic Acid A (sc-391058), to avoid stability problems associated with hydrolysis of the salt.
Bergstrom, J.D. Proc. Natl. Acad. Sci. U. S. A. 90, 80, (1993) Bergstrom, J.D. Annu. Rev. Microbiol. 49, 607, (1995) Kennedy, M.A. Biochim. Biophys. Acta 1445, 110, (1999) Petras, S.F., et al. J. Lipid Res. 40, 24, (1999)
Soluble in ethanol (10 mg/ml), and DMSO (10 mg/ml, heating may be required).
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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LiuLiu, CI. et al. (PubMed 22474324) determined the structure of Zaragozic acid A (ZA-A), a potent inhibitor, in vivo and in vitro, of mammalian, fungal and Saccharomyces cervisiae squalene synthase (SQS), complexed with human SQS. ZA-A binding induces a local conformational change in the substrate binding site, and its C-6 acyl group also extends over to the cofactor binding cavity. -SCBT Publication Review
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