Zaragozic Acid A A squalene synthetase inhibitor

Zaragozic Acid A (CAS 142561-96-4)

Zaragozic Acid A | CAS 142561-96-4 is rated 5.0 out of 5 by 1.
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Synonym: Squalestatin A
Application: A squalene synthetase inhibitor
CAS Number: 142561-96-4
Purity: ≥98%
Molecular Weight: 690.73
Molecular Formula: C35H46O14
* Refer to Certificate of Analysis for lot specific data (including water content).
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Zaragozic acid A is a potent inhibitor of mammalian, fungal and Saccharomyces cervisiae squalene synthase. As a squalene synthase inhibitor, zaragozic acid has been shown to produce lower plasma cholesterol levels in primates.

Physical State :
Solid
Derived From :
Unidentified fungus
Solubility :
Soluble in ethanol (10 mg/ml), methanol, DMF, DMSO (10 mg/ml), and water (moderate).
Storage :
Store at -20° C
Boiling Point :
~850.1 °C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
IC50 :
Squalene synthetase: IC50 = 0.5 nM (human); Squalene synthetase: IC50 = 12 nM (rat)
pK Values :
pKa: 1.47 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
6438355
MDL Number :
MFCD03788025
SMILES :
CC[C@H](C)C[C@H](C)/C=C/C(=O)O[C@@H]1[C@H]([C@]2(O[C@@H]([C@]([C@@]1(O2)C(=O)O)(C(=O)O)O)C(=O)O)CCC(=C)[C@H]([C@H](C)CC3=CC=CC=C3)OC(=O)C)O

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Certificate of Analysis

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Rated 5 out of 5 by from Gabriel Gabriel, HB. et al. (PubMed 25779575) reported that the antifungal Zaragozic Acid A (Squalestatin A) is an inhibitor of carotenoid biosynthesis in Plasmodium falciparum. -SCBT Publication Review
Date published: 2015-06-30
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