Zaragozic acid A is a potent inhibitor of mammalian, fungal and Saccharomyces cervisiae squalene synthase. As a squalene synthase inhibitor, zaragozic acid has been shown to produce lower plasma cholesterol levels in primates.
Soluble in ethanol (10 mg/ml), methanol, DMF, DMSO (10 mg/ml), and water (moderate).
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GabrielGabriel, HB. et al. (PubMed 25779575) reported that the antifungal Zaragozic Acid A (Squalestatin A) is an inhibitor of carotenoid biosynthesis in Plasmodium falciparum. -SCBT Publication Review
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