Z-WEHD-FMK An inhibitor of caspase-1, caspase-4, caspase-5 and caspase-8

Z-WEHD-FMK

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Synonym: Benzyloxycarbonyl-Trp-Glu(OMe)-His-Asp(OMe)-fluoromethylketone
Application: An inhibitor of caspase-1, caspase-4, caspase-5 and caspase-8
Molecular Weight: 763.78
Molecular Formula: C37H42FN7O10
* Refer to Certificate of Analysis for lot specific data (including water content).
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Z-WEHD-FMK is a potent, cell-permeable, and irreversible inhibitor of caspase-5. It also inhibits caspase-1, caspase-4 and caspase-8. Caspase inhibitors play an important role in investigating biological processes. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Following use of the inhibitor, standard apoptosis assays can then be used to examine treated cells for evidence of apoptosis.
For the fluorometric determination of caspase-6 activity, the following caspase apoptosis detection kit is available from Santa Cruz: Caspase-6 Kit (sc-4266 AK).

Physical State :
Solid
Sequence :
Z-Trp-Glu(OMe)-His-Asp(OMe)-FMK
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
25108687
SMILES :
COC(=O)CC[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)[C@H](CC2=CNC3=CC=CC=C32)NC(=O)OCC4=CC=CC=C4

Download SDS (MSDS)

Certificate of Analysis

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