Z-VDVAD-FMK (Caspase-2 inhibitor) is a cell-permeable, irreversible inhibitor of caspase-2. Caspase inhibitors play an important role in investigating biological processes. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. In a study of 7-ketocholesterol (sc-210630)-induced cell death and the association with polar lipid accumulation, the effects of Z-VDVAD-FMK on the lipid profile was evaluated by staining with Nile Red (sc-203747). Z-VDVAD-FMK has also been shown to inhibit programmed macrophage cell death induced by Brucella species gram-negative bacteria.
Purity: Single spot by TLC.
1. Vejux, A. et al. 2007. Cytometry A. 71(8): 550-562. PMID: 17458884 2. Chen, F. and He, Y. 2009. PLoS ONE. 4(8): e6830. PMID: 19714247
Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 3 months at -20°C.
Soluble in DMSO (13.91 mg/ml), and DMSO/DMF (20 mM).
Store at -20° C
980.10° C at 760 mmHg (Predicted)
1.23 g/cm3 (Predicted)
n20D 1.51 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of
Vigneswara V; et alVigneswara V; et al. (PubMed ID: 23285297) determined that Z-VDVAD-FMK decreased cleaved caspase-2 activation and rescued retinal ganglion cells. -SCBT Publication Review
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
Create a new account
Email address already exists, please enter a new valid email address.
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.