Z-VDVAD-FMK An irreversible inhibitor of Caspase-2

Z-VDVAD-FMK

Z-VDVAD-FMK is rated 5.0 out of 5 by 1.
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Synonym: Benzyloxycarbonyl-Val-Asp(OMe)-Val-Ala-Asp(OMe)-fluoromethylketone
Application: An irreversible inhibitor of Caspase-2
Molecular Weight: 695.73
Molecular Formula: C32H46FN5O11
* Refer to Certificate of Analysis for lot specific data (including water content).
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Z-VDVAD-FMK (Caspase-2 inhibitor) is a cell-permeable, irreversible inhibitor of caspase-2. Caspase inhibitors play an important role in investigating biological processes. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. In a study of 7-ketocholesterol (sc-210630)-induced cell death and the association with polar lipid accumulation, the effects of Z-VDVAD-FMK on the lipid profile was evaluated by staining with Nile Red (sc-203747). Z-VDVAD-FMK has also been shown to inhibit programmed macrophage cell death induced by Brucella species gram-negative bacteria.

Purity: Single spot by TLC.


References

1. Vejux, A. et al. 2007. Cytometry A. 71(8): 550-562. PMID: 17458884
2. Chen, F. and He, Y. 2009. PLoS ONE. 4(8): e6830. PMID: 19714247

Usage :
Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 3 months at -20°C.
Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (13.91 mg/ml), and DMSO/DMF (20 mM).
Storage :
Store at -20° C
Boiling Point :
980.10° C at 760 mmHg (Predicted)
Density :
1.23 g/cm3 (Predicted)
Refractive Index :
n20D 1.51 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
25108684
MDL Number :
MFCD03452881
SMILES :
C[C@@H](C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(=O)OC)NC(=O)[C@H](C(C)C)NC(=O)OCC1=CC=CC=C1

Download SDS (MSDS)

Certificate of Analysis

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Z-VDVAD-FMK  Product Citations

See how others have used Z-VDVAD-FMK. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 24204395  Wu, CC. et al. 2013. Evidence-based complementary and alternative medicine : eCAM. 2013: 548929.

PMID: # 19118032  Trougakos, IP. et al. 2009. Clin. Cancer Res. 15: 48-59.

PMID: # 19154411  Lee, JC. et al. 2009. Cancer science. 100: 503-13.

PMID: # 17082817  Hanoux, V. et al. 2007. Cell Death Differ. 14: 671-81.

Citations 1 to 4 of 4 total
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Rated 5 out of 5 by from Vigneswara V; et al Vigneswara V; et al. (PubMed ID: 23285297) determined that Z-VDVAD-FMK decreased cleaved caspase-2 activation and rescued retinal ganglion cells. -SCBT Publication Review
Date published: 2015-01-12
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