Z-VAD-FMK is an irreversible, cell-permeable, broad-spectrum caspase inhibitor. Z-VAD-FMK limited Fas-induced mouse liver damage and apoptosis to <1% and abrogated 7-hydroxystaurosporine and etoposide-induced apoptosis in HL60 cells at 50 μM.
Note: product is now supplied in lyophilized format for customer to dissolve in their own high-quality DMSO or other applicable solvent.
sc-3067 is supplied in a convenient, 0.5 mg aliquot. Larger quantities available as sc-311561.
1. Chow, S.C., et al. 1995. FEBS Lett. 364: 134-138. PMID: 7538469 2. Zhu, H., et al. 1995. FEBS Lett. 374: 303-308. PMID: 7589559 3. Slee, E.A., et al. 1996. Biochem. J. 315: 21-24. PMID: 8670109 4. Shao, R.G., et al. 1997. J. Biol. Chem. 272: 31321-31325. PMID: 9395460 5. Chandler, J.M., et al. 1998. J. Biol. Chem. 273: 10815-10818. PMID: 9556551 6. Warny, M., et al. 1999. Am. J. Physiol. 276: C717-C724. PMID: 10070000 7. Mundle, S.D., et al. 1999. Cancer Lett. 140: 201-207. PMID: 10403560 8. Farber, A., et al. 1999. J. Vasc. Surg. 30: 752-760. PMID: 10514215 9. Piguet, P.F., et al. 1999. Lab. Invest. 79: 495-500. PMID: 10212002 10. Shimohama, S., 2000. Apoptosis. 5: 9-16. PMID: 11227497 11. Wiessner, C., et al. 2000. Cell. Mol. Biol. 46: 53-62. PMID: 10726971 12. Barsoum, M.J., et al. 2006. EMBO J. 25: 3900-3911. PMID: 16874299
Stable for up to 1 year after receipt when stored at -20°C. Stock solutions should be aliquoted and stored at -20°C for up to 1 month.
Store at -20° C
n20D 1.51 (Predicted)
caspase processing and apoptosis: IC50 = 0.0015 - 5.8 mM (tumor cells)
pKa: 11.05 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Is it possible to use this product to inhibit purified caspases?
Asked by: Adam1215
Thank you for your question. Z-VAD-FMK (CAS 187389-52-2) is an irreversible, cell-permeable, broad-spectrum caspase inhibitor. For information about how other researchers have used this chemical in their research, please refer to the list of product references on our website (listed below the Description, below the ordering information).
Answered by: Technical Support
Date published: 2017-01-03
What is the solubility of this product?
Asked by: hawkeye11
Thank you for your question.
This chemical is soluble in DMSO at 20mM concentration.
Please contact Technical Service if you have further questions concerning this product.
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