Z-DEVD-FMK An inhibitor of caspase-3, caspase-6, caspase-7, and caspase-10

Z-DEVD-FMK (CAS 210344-95-9)

Z-DEVD-FMK | CAS 210344-95-9 is rated 5.0 out of 5 by 1.
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Synonym: Caspase-3 Inhibitor; Z-D(OMe)E(Ome)VD(OMe)-FMK
Application: An inhibitor of caspase-3, caspase-6, caspase-7, and caspase-10
CAS Number: 210344-95-9
Purity: ≥98%
Molecular Weight: 668.66
Molecular Formula: C30H41N4O12F
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Z-DEVD-FMK is a cell-permeable, irreversible inhibitor of Caspase-3/CPP32. It is also an irreversible inhibitor of Caspase-6, Caspase-7, caspase-8, and Caspase-10. Z-DEVD-FMK has been shown to inhibit tumor cell apoptosis.


References

1. Brockstedt, E., et al., 1998. Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line. Cleavage of heterogeneous nuclear ribonucleoprotein A1 by caspase 3. The Journal of biological chemistry. 273(43): 28057-64. PMID: 9774422<BR> 2. Henshall, D C., et al., 2000. Involvement of caspase-3-like protease in the mechanism of cell death following focally evoked limbic seizures. Journal of neurochemistry. 74(3): 1215-23. PMID: 10693954<BR> 3. Kugawa, F., et al., 2000. Apoptosis of NG108-15 cells induced by buprenorphine hydrochloride occurs via the caspase-3 pathway. Biological & pharmaceutical bulletin. 23(8): 930-5. PMID: 10963298<BR> 4. Chen, X. et al. 2015. Brain Res. 1625 : 275-286. PMID: 26367448<br>

Usage :
After reconstitution, prepare aliquots and store at -20°C.

We recommend a final concentration of 2-10µM for inhibiting caspase activity in cell culture. The optimal doses may vary for different cells and culture conditions.
Physical State :
Solid
Sequence :
Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone
Solubility :
Soluble in DMSO (20 mM), and DMF.
Storage :
Store at -20° C
Boiling Point :
~914.2° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.51 (Predicted)
IC50 :
caspase-3 : IC50 = 130 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
16760394
MDL Number :
MFCD23380217
SMILES :
CC(C)[C@@H](C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)[C@H](CCC(=O)OC)NC(=O)[C@H](CC(=O)OC)NC(=O)OCC1=CC=CC=C1

Download SDS (MSDS)

Certificate of Analysis

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Z-DEVD-FMK  Product Citations

See how others have used Z-DEVD-FMK. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 24 total

PMID: # 28288862  Fan, C. et al. 2017. Neurosci. Lett. 651: 198-206.

PMID: # 28499910  Aseer, KR. et al. 2017. Free Radic. Biol. Med. 108: 874-895.

PMID: # 26911899  Tian, F. et al. 2016. Scientific reports. 6: 21992.

PMID: # 27144333  Harrison, JS. et al. 2016. Oncotarget. 7: 36447-36460.

PMID: # 26519528  Stammler, D. et al. 2015. J. Immunol. 195: 5421-31.

PMID: # 26367448  Chen, X. et al. 2015. Brain Res. 1625: 275-86.

PMID: # 26657638  Marnef, A. et al. 2015. Nucleic Acids Res.

PMID: # 25596736  Zhang, J. et al. 2015. Oncotarget. 6: 789-801.

PMID: # 24337868  Philippe, L. et al. 2014. Apoptosis. 19: 436-50.

PMID: # 25356863  Yoon, S. et al. 2014. Cell Death Dis. 5: e1494.

Citations 1 to 10 of 24 total

What is the solubility of this compound?

Asked by: two2igm05
Thank you for your question. This chemical, Z-DEVD-FMK: sc-311558, is soluble in DMSO and DMF at &ge;20mM.
Answered by: Chemical Support 2
Date published: 2017-02-24

Can this product be used in HPLC analysis?

Asked by: SCchem16
Thank you for your question. This chemical, Z-DEVD-FMK (CAS 210344-95-9), is suitable to be analyzed by HPLC.
Answered by: Chemical Support 2
Date published: 2017-02-24
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Rated 5 out of 5 by from Chen Chen, X. et al. (PubMed 26367448) used Z-DEVD-FMK, an inhibitor of caspase-3, caspase-6, caspase-7, and caspase-10, to demonstrate the involvment of caspase-3/PTEN signaling pathway in isoflurane-induced decrease of self-renewal capacity of hippocampal neural precursor cells. -SCBT Publication Review
Date published: 2015-02-17
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