Z-DEVD-FMK is a cell-permeable, irreversible inhibitor of Caspase-3/CPP32. It is also an irreversible inhibitor of Caspase-6, Caspase-7, caspase-8, and Caspase-10. Z-DEVD-FMK has been shown to inhibit tumor cell apoptosis.
1. Brockstedt, E., et al., 1998. Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line. Cleavage of heterogeneous nuclear ribonucleoprotein A1 by caspase 3. The Journal of biological chemistry. 273(43): 28057-64. PMID: 9774422<BR> 2. Henshall, D C., et al., 2000. Involvement of caspase-3-like protease in the mechanism of cell death following focally evoked limbic seizures. Journal of neurochemistry. 74(3): 1215-23. PMID: 10693954<BR> 3. Kugawa, F., et al., 2000. Apoptosis of NG108-15 cells induced by buprenorphine hydrochloride occurs via the caspase-3 pathway. Biological & pharmaceutical bulletin. 23(8): 930-5. PMID: 10963298<BR> 4. Chen, X. et al. 2015. Brain Res. 1625 : 275-286. PMID: 26367448<br>
After reconstitution, prepare aliquots and store at -20°C.
We recommend a final concentration of 2-10µM for inhibiting caspase activity in cell culture. The optimal doses may vary for different cells and culture conditions.
Rated 5 out of
ChenChen, X. et al. (PubMed 26367448) used Z-DEVD-FMK, an inhibitor of caspase-3, caspase-6, caspase-7, and caspase-10, to demonstrate the involvment of caspase-3/PTEN signaling pathway in isoflurane-induced decrease of self-renewal capacity of hippocampal neural precursor cells. -SCBT Publication Review
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