Z-Asp-2,6-dichlorobenzoyloxymethylketone (Z-Asp-CH2-DCB), a cell permeable broad Caspase Inhibitor, prevents development of severe pulmonary hypertension and intravascular pulmonary endothelial cell growth caused by chronic hypoxia in murine models. This compound has also been shown to prevent des-ring B colchicine induced apoptosis of cells. Evaluation of Z-Asp-CH2-DCB on caspase inhibition has shown a reduced rate of cleavage of Troponin I-C, an important component of cardiac contractile apparatus. Z-Asp-2,6-dichlorobenzoyloxymethylketone is an inhibitor of caspase-3 and caspase-6.
1. Gajate, C., et al. 2000. Cancer Res. 60: 2651-2659. PMID: 10825137 2. Taraseviciene-Stewart, L., et al. 2001. FASEB J. 15: 427-438. PMID: 11156958 3. Chandrashekhar, Y., et al. 2004. J. Am. Coll. Cardiol. 43: 295-301. PMID: 14736452
Soluble in DMSO (5 mg/ml), and methanol (50 mg/ml). Insoluble in water.
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DrognitzDrognitz, O. et al. (PubMed 15196060) investigated the effects of organ preservation, ischemia time and caspase inhibition on apoptosis and microcirculation in rat pancreas transplantation. Pancreatic grafts were subjected to different preservation solutions and cold ischemia times (CITs). One graft was subjected to normal saline, 6-h CITs with Z-Asp-2,6-dichlorobenzoyloxymethylketone (pan-caspase inhibitor). Non-transplanted animals served as controls. -SCBT Publication Review
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