Z-Asp-2,6-dichlorobenzoyloxymethylketone A broad Caspase Inhibitor

Z-Asp-2,6-dichlorobenzoyloxymethylketone (CAS 153088-73-4)

Z-Asp-2,6-dichlorobenzoyloxymethylketone | CAS 153088-73-4 is rated 5.0 out of 5 by 1.
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Synonym: Caspase-1 Inhibitor V
Application: A broad Caspase Inhibitor
CAS Number: 153088-73-4
Purity: >98%
Molecular Weight: 454.3
Molecular Formula: C20H17Cl2NO7
* Refer to Certificate of Analysis for lot specific data (including water content).
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Z-Asp-2,6-dichlorobenzoyloxymethylketone (Z-Asp-CH2-DCB), a cell permeable broad Caspase Inhibitor, prevents development of severe pulmonary hypertension and intravascular pulmonary endothelial cell growth caused by chronic hypoxia in murine models. This compound has also been shown to prevent des-ring B colchicine induced apoptosis of cells. Evaluation of Z-Asp-CH2-DCB on caspase inhibition has shown a reduced rate of cleavage of Troponin I-C, an important component of cardiac contractile apparatus. Z-Asp-2,6-dichlorobenzoyloxymethylketone is an inhibitor of caspase-3 and caspase-6.


References

1. Gajate, C., et al. 2000. Cancer Res. 60: 2651-2659. PMID: 10825137
2. Taraseviciene-Stewart, L., et al. 2001. FASEB J. 15: 427-438. PMID: 11156958
3. Chandrashekhar, Y., et al. 2004. J. Am. Coll. Cardiol. 43: 295-301. PMID: 14736452

Physical State :
Solid
Solubility :
Soluble in DMSO (5 mg/ml), and methanol (50 mg/ml). Insoluble in water.
Storage :
Store at -20° C
Melting Point :
233.45° C (Predicted)
Boiling Point :
674.22° C at 760 mmHg (Predicted)
Density :
1.44 g/cm3 (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
IC50 :
Caspase-3: IC50 = 1.1 µM; Caspase-6: IC50 = 4.1 µM
pK Values :
pKa: 4.01 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
9911778
MDL Number :
MFCD00674885
SMILES :
C1=CC=C(C=C1)COC(=O)NC(CC(=O)O)C(=O)COC(=O)C2=C(C=CC=C2Cl)Cl

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Drognitz Drognitz, O. et al. (PubMed 15196060) investigated the effects of organ preservation, ischemia time and caspase inhibition on apoptosis and microcirculation in rat pancreas transplantation. Pancreatic grafts were subjected to different preservation solutions and cold ischemia times (CITs). One graft was subjected to normal saline, 6-h CITs with Z-Asp-2,6-dichlorobenzoyloxymethylketone (pan-caspase inhibitor). Non-transplanted animals served as controls. -SCBT Publication Review
Date published: 2015-02-01
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