Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
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Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
The type II cAMP-dependent protein kinase (PKA) is a multifunctional kinase with a broad range of substrates. Specificity of PKA signaling is mediated by the compartmentalization of the kinase to specific sites within the cell. To maintain this specific localization, the R subunit (RII) of PKA interacts with specific RII-anchoring proteins. This family of proteins is designated A-kinase anchoring proteins (AKAP). AKAP 9, also designated AKAP 450, is a 3,911 amino acid protein which undergoes alternative splicing resulting in multiple isoforms including, AKAP 350 and Yotiao. Research has found AKAP 9 localized to both centrosomes and the Golgi apparatus throughout the cell cycle, and it is suggested that AKAP 9 may function as a scaffolding protein assembling protein kinases and phosphatases based on substrate-specific phosphorylation. An N-terminal sequence from amino acids 1-1626 is identical between the AKAP 9 and Yotiao proteins. The unique C-terminus of the Yotiao isoform contains an additional 12 amino acid sequence not shared with AKAP 9. Yotiao is expressed primarily in pancreas and skeletal muscle. Yotiao interacts with the NR1 sub-unit of the NMDA receptor. Co-assembly of Yotiao/PKAII complexes with NR1 subunits promote cAMP-dependent modulation of NMDA receptor activity at synapses, thereby influencing brain development and synaptic plasticity.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
What is the recommended fixation method for immunofluorescence staining with Yotiao (7): sc-136177 monoclonal antibody?
Asked by: TinTin
Thank you for your inquiry. We recommend fixing cells for 5 minutes in -10ºC methanol and allowing to air dry. The full protocol can be viewed here:
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