YC-1 YC-1, a compound that can activate platelet soluble guanylate cylcase (sGC) indepedent of nitric oxide activation.

YC-1  (CAS 170632-47-0)

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Synonym: 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole
Application: An agent that can activate sGC independent of nitric oxide activation
CAS Number: 170632-47-0
Purity: >99%
Molecular Weight: 304.34
Molecular Formula: C19H16N2O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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YC-1 sc-202856 1 mg $31.00

YC-1 can activate platelet soluble GCS (guanylate cylcase) indepedent of nitric oxide activation. It has the ability to inhibit aggregation of platelets and increase the platelets cAMP and cGMP content, as well as act as an antithrombotic compound. Data shows that the highest activation of GCS is observed in the presence of YC-1. The compound can suppress HIF-1 α activity in neonatal rat ventricular myocytes. Research shows that GCS activators (YC-1) might have the ability to activate the sGC/cGMP/PKG pathway and influence the activation of Ras/Raf-1/p44/42 MAPK. YC-1 is an activator of GCS (guanylate cylcase). YC-1 is an inhibitor of HIF-1 α.


1. Ko, F.N., et al. 1994. Blood. 84: 4226-4233. PMID: 7527671
2. Wu, C.C., et al. 1995. Br. J. Pharmacol. 116: 1973-1978. PMID: 8640334
3. Stone, J.R. and Marletta, M.A. 1998. Chem. Biol. 5: 255-261. PMID: 9646941
4. Chang, M.S., et al. 2009. Pharmacol. Res. 60: 247-253. PMID: 19717011
5. Zhou, Y.F., et al. 2010. Cardiovasc J Afr. 21: 37-41. PMID: 20224844

Physical State :
Solubility :
Soluble in DMSO (12 mg/ml), methanol (5 mg/ml), ethanol (50 mM), DMF (~20 mg/ml), 5:2 DMSO:PBS(pH 7.2) (~10 ug/ml), and dichloromethane. Insoluble in water.
Storage :
Store at -20° C
Melting Point :
110-113° C
Boiling Point :
~522.17° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.65 (Predicted)
IC50 :
soluble guanylyl cyclase: EC5050 = 18.6 µM; collagen (10 µg/ml) induced platelet aggregation: IC50 = 11.7-14.6 µM; thrombin (0.1 U/ml) induced platelet aggregation: IC50 = 57.3-59.3 µM; Guanylate cyclase soluble alpha-1 chain: EC5050 = 4.11 µM (Bos taurus); ACHN: IC50 = 300 nM (human); hypoxia-induced HIF-1 transcriptional activity: IC50 = 1.2 µM; NCI-H226: IC50 = 1.9 µM (human); Hypoxia-inducible factor 1 alpha: IC50 = 2 µM (human); AGS: IC50 = 2 µM (human)
pK Values :
pKa: 13.83 (Predicted), pKb: 1.15 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
MDL Number :

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Certificate of Analysis

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PMID: # 24550991
Santos, AI. et al. 2014. Stimulation of neural stem cell proliferation by inhibition of phosphodiesterase 5. Stem cells international. 2014: 878397.

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Rated 5 out of 5 by from Wang X; et al Wang X; et al. (PubMed ID: 26350953) utilized YC-1, HIF1a inhibitor, to determine the effect of HIF1a in hypoxia induced down-regulation of BCL-2 and up-regulation of miR-20. -SCBT Publication Review
Date published: 2015-02-07
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