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YC-1 can activate platelet soluble GCS (guanylate cylcase) indepedent of nitric oxide activation. It has the ability to inhibit aggregation of platelets and increase the platelets cAMP and cGMP content, as well as act as an antithrombotic compound. Data shows that the highest activation of GCS is observed in the presence of YC-1. The compound can suppress HIF-1 α activity in neonatal rat ventricular myocytes. Research shows that GCS activators (YC-1) might have the ability to activate the sGC/cGMP/PKG pathway and influence the activation of Ras/Raf-1/p44/42 MAPK. YC-1 is an activator of GCS (guanylate cylcase). YC-1 is an inhibitor of HIF-1 α.
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See how others have used YC-1. Click on the entry to view the PubMed entry .
PMID: # 24550991
Santos, AI. et al. 2014. Stimulation of neural stem cell proliferation by inhibition of phosphodiesterase 5. Stem cells international. 2014: 878397.
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