A highly potent, cell-permeable, selective ROCK (Rho-associated coiled coil forming protein serine/threonine kinase) inhibitor. Ki = 140 nM for p160 ROCK. It also inhibits ROCK-II with equal potency where the inhibition is competitive with respect to ATP.
Davies, S.P., et al., Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J. 351, 95-105, (2000); Maekawa, M., et al., Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase. Science 389, 895-898 , (1999)
See how others have used Y-27632 dihydrochloride monohydrate. Click on the entry to view the PubMed entry .
PMID: # 28088685 Price, AJ. et al. 2017. Biomaterials. 121: 179-192.
PMID: # 26870238 Xiong, W. et al. 2016. Oncol Lett. 11: 484-490.
PMID: # 25595902 Li, G. et al. 2015. Oncotarget. 6: 1834-49.
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