Y-27632 dihydrochloride monohydrate A cell-permeable ROCK inhibitor

Y-27632 dihydrochloride monohydrate (CAS 331752-47-7)

Y-27632 dihydrochloride monohydrate | CAS 331752-47-7 is rated 5.0 out of 5 by 1.
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Synonym: Rock Inhibitor
Application: A cell-permeable ROCK inhibitor
CAS Number: 331752-47-7
Molecular Weight: 338.27
Molecular Formula: C14H21N3O 2HCl H2O
* Refer to Certificate of Analysis for lot specific data (including water content).
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A highly potent, cell-permeable, selective ROCK (Rho-associated coiled coil forming protein serine/threonine kinase) inhibitor. Ki = 140 nM for p160 ROCK. It also inhibits ROCK-II with equal potency where the inhibition is competitive with respect to ATP.


References

Davies, S.P., et al., Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J. 351, 95-105, (2000); Maekawa, M., et al., Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase. Science 389, 895-898 , (1999)

Physical State :
Solid
Solubility :
Soluble in Water: 14 mg/mL
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
123862
SMILES :
CC(C1CCC(CC1)C(=O)NC2=CC=NC=C2)N.Cl.Cl

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Certificate of Analysis

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Y-27632 dihydrochloride monohydrate  Product Citations

See how others have used Y-27632 dihydrochloride monohydrate. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 28088685  Price, AJ. et al. 2017. Biomaterials. 121: 179-192.

PMID: # 26870238  Xiong, W. et al. 2016. Oncol Lett. 11: 484-490.

PMID: # 25595902  Li, G. et al. 2015. Oncotarget. 6: 1834-49.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from Okumura Okumura, N. et al. (PubMed 26393474) investigated the effect of the Rho kinase inhibitor (ROCK) Y-27632 on corneal endothelial wound healing in a rabbit model. In the corneal endothelial damage rabbit model, more Ki67-positive cells were detected in Y-27632-treated eyes than in control eyes. Five of six corneas became transparent in Y-27632-treated eyes, whereas zero of six corneas became transparent in the control eyes (P < 0.01). -SCBT Publication Review
Date published: 2015-07-04
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