Xanthorrhizol A pro-apoptotic inhibitor of Cox-2 and NOS2

Xanthorrhizol (CAS 30199-26-9)

Xanthorrhizol | CAS 30199-26-9 is rated 5.0 out of 5 by 1.
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Synonym: 1,3,5,10-Bisabolatetraen-2-ol
Application: A pro-apoptotic inhibitor of Cox-2 and NOS2
CAS Number: 30199-26-9
Purity: >97%
Molecular Weight: 218.33
Molecular Formula: C15H22O
* Refer to Certificate of Analysis for lot specific data (including water content).
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Xanthorrhizol is an antibacterial and antiinflammatory compound that can induce apoptosis and inhibit Cox-2 and NOS2. Research shows that xanthorrhizol has calcium antagonist activity, which may be due to blockage of voltage operated calcium influx in myometrial cells. The xanthorrhizol compound can increase p53 and protein Bax expression in HeLa cells and induce apoptosis in HepG2 cells. Data has shown decrease in protein expression of ornithine decarboxylase (ODC), cyclooxygenase-2 (COX-2), nitric oxide synthase (iNOS), and mitogen activated protein kinases in the presence of xanthorrhizol.


References

1. Ponce-Monter, H., et al. 1999. Phytother Res. 13: 202-205. PMID: 10353157
2. Hwang, J.K., et al. 2000. Planta Med. 66: 196-197. PMID: 10763606
3. Ismail, N., et al. 2005. Anticancer Res. 25: 2221-2227. PMID: 16158967
4. Handayani, T., et al. 2007. Anticancer Res. 27: 965-971. PMID: 17465228
5. Chung, W.Y., et al. 2007. Carcinogenesis. 28: 1224-1231. PMID: 17234720

Appearance :
Oil
Physical State :
Liquid
Derived From :
Curcuma xanthorrhiza
Solubility :
Soluble in 100% ethanol, DMSO, and water (slightly).
Storage :
Store at -20° C
Melting Point :
86.82° C (Predicted)
Boiling Point :
~326.90° C at 760 mmHg (Predicted)
Density :
~0.9 g/mL (Predicted)
Refractive Index :
n20D 1.52 (Predicted)
pK Values :
pKa: 10.34 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
93135
MDL Number :
MFCD03453037
EC Number :
250-090-2
SMILES :
CC1=C(C=C(C=C1)C(C)CCC=C(C)C)O

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Certificate of Analysis

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Xanthorrhizol  Product Citations

See how others have used Xanthorrhizol. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 17234720  Chung, WY. et al. 2007. Carcinogenesis. 28: 1224-1231.

Citations 1 to 1 of 1 total

Respected sir, I am G. Annamalai, doing Ph.D (Biotechnology) in Annamalai university, Annamalai nagar, Tamil nadu, India. I need 20 mg of Xanthorrhizol for my research purpose. so I need quotation for these compound. Thank you

Asked by: Annamalai G
Thank you for your question. To receive an accurate quote for this chemical including shipping, please contact one of our authorized distributors in India. A link to search for our regional distributors is provided below. https://www.scbt.com/scbt/resources/distributors
Answered by: Technical Support
Date published: 2018-04-13
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Rated 5 out of 5 by from Chung Chung, WY. et al. (PubMed 17234720) found that topical application of Xanthorrhizol significantly inhibited TPA-induced mouse ear edema and TPA-induced tumor promotion in 7,12-dimethylbenz[a]anthracene (DMBA)-initiated ICR mouse skin. -SCBT Publication Review
Date published: 2015-04-30
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