Xanthohumol from hop (Humulus lupulus) An inhibitor of cytochrome P450 enzymes

Xanthohumol from hop (Humulus lupulus) (CAS 6754-58-1)

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Application: An inhibitor of cytochrome P450 enzymes
CAS Number: 6754-58-1
Molecular Weight: 354.40
Molecular Formula: C21H22O5
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Xanthohumol from hop (Humulus lupulus) sc-301982 5 mg $249.00

Xanthohumol from hop (Humulus lupulus) has demonstrated antiproliferative and cytotoxic effects in human cancer cell lines. It has been shown to inhibit DGAT (diacylglycerol acetyltransferase) and human CYP (cytochrome P450 enzymes). It has also been shown to inhibit the expression of HIF-1α and VEGF under hypoxic conditions. Xanthohumol from hop (Humulus lupulus) is an inhibitor of DNA Polymerase, VCP and PKB Kinase.


References

1. Miranda, C.L. et. al., Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines. Food Chem. Toxicol. 37, 271-285, (1999) 2. Tabata, N. et. al., Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus lupulus. Phytochemistry 46, 683-687, (1997) 3. Henderson, M.C., et. al., In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus. Xenobiotica 30, 235-251, (2000) 4. Gerhauser, C. et. al., Cancer chemopreventive activity of xanthohumol, a natural product derived from hop. Mol. Cancer Ther. 1, 959-969, (2002)

Physical State :
Solid
Solubility :
Soluble in ethanol (10 mg/mL), DMSO (25 mg/mL), methanol (10 mg/mL), and aqueous buffers (20 µM).
Storage :
Store at -20° C
Melting Point :
157-159° C
Boiling Point :
576.5° C at 760 mmHg
Density :
1.24 g/cm3
Refractive Index :
n20D 1.64 ± 0.02
IC50 :
Plasmodium falciparum: IC50 = 8.2 µM; RAW264.7 : IC50 = 8.3 µM (mouse); HeLa: IC50 = 9.4 µM (human); immunodeficiency virus 1: EC5050 = 0.5 ug/mL (human)
pK Values :
pKa: 7.59 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UD5574117
Transport :
UN 3077, Class 9, Packing group III
PubChem CID :
639665
MDL Number :
MFCD00210576
SMILES :
CC(=CCC1=C(C=C(C(=C1O)C(=O)/C=C/C2=CC=C(C=C2)O)OC)O)C

Download SDS (MSDS)

Certificate of Analysis

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