This product is a fluorescent bisintercalating anthracycline antibiotic. It has been shown to inhibit basal transcription by RNA polymerase II.
Chaires, J .B., et al., Structure-based design of a new bisintercalating anthracycline antibiotic. J. Med. Chem. J. Med. Chem. 40, 261-266, (1997) Martin, B., et al., Bisanthracycline WP631 inhibits basal and Sp1-activated transcription initiation in vitro. Nucleic Acids Res. 27, 3402-3409, (1999) Portugal, J., et al., Analysis of the effects of daunorubicin and WP631 on transcription. Curr. Med. Chem. 8, 1-8, (2001) Silvia Villamarin, S., et al., Induction of G2/M arrest and inhibition of c-myc and p53 transcription by WP631 in Jurkat T lymphocytes. Biochem. Pharmacol. 63, 1251-1258, (2002) Gaidarova, S., and Jimenez, S.A., Inhibition of Basal and Transforming Growth Factor-beta -induced Stimulation of COL1A1 Transcription by the DNA Intercalators, Mitoxantrone and WP631, in Cultured Human Dermal Fibroblasts. J. Biol. Chem. 277, 38737-38745, (2002)
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