Wnt Synergist, QS11 An ARFGAPs inhibitor and Wnt-3a synergist

Wnt Synergist, QS11 (CAS 944328-88-5)

Wnt Synergist, QS11 | CAS 944328-88-5 is rated 5.0 out of 5 by 1.
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Synonym: QS 11
Application: An ARFGAPs inhibitor and Wnt-3a synergist
CAS Number: 944328-88-5
Purity: ≥95%
Molecular Weight: 567.68
Molecular Formula: C36H33N5O2
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Wnt Synergist, QS11 is a cell-permeable purine compound that binds GTPase activating proteins of ADP-ribosylation factor (ARFGAPs), including AMAP1 (Kd = 364 nM) and ARFGAP1 (Kd = 620 nM) and acts as a broad specificity ARFGAP1 inhibitor. Wnt Synergist, QS11 has also been reported to block the migration of AMAP1-overexpressing MDA-MB-231 cells (86% inhibition at 2.5 μM).

Additionally, Wnt Synergist, QS11 has been shown to work synergistically with Wnt-3a to specifically activate the Wnt/β-catenin signaling pathway in vitro. A Super(8X)TOPFlash reporter assay using HEK293 cells revealed increases in basal transcription activity by application of QS11 (2-fold), Wnt-3a (40-fold), and QS11/Wnt-3a (200-fold).


References

1. Zhang, Qisheng., et al., 2007. Small-molecule synergist of the Wnt/beta-catenin signaling pathway. Proceedings of the National Academy of Sciences of the United States of America. 104(18): 7444-8. PMID: 17460038

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and ethanol (100 mM).
Storage :
Store at 4° C
Boiling Point :
~852.19° C at 760 mmHg (Predicted)
Density :
~1.28 g/cm3 (Predicted)
Refractive Index :
n20D 1.68 (Predicted)
IC50 :
HEK293: EC5050 = 500 nM (human)
pK Values :
pKb: 1.49 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
42623900
SMILES :
C1CC2=C(C1)C=C(C=C2)OC3=NC4=C(C(=N3)N[C@@H](CC5=CC=CC=C5)CO)N=CN4CC6=CC=C(C=C6)C7=CC=CC=C7

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Zhang Zhang, Q. et al. (PubMed 17460038) used affinity chromatography and subsequent functional assays to show that Wnt Synergist, QS11 binds and inhibits the GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1). -SCBT Publication Review
Date published: 2015-05-02
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