Wee 1/Chk1 InhibitorA potent inhibitor of checkpoint kinases Wee 1 and Chk1

Wee 1/Chk1 Inhibitor (CAS 1177150-89-8)

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Synonym: 4-(2-Phenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3-(2H,6H)-dione
Application: A potent inhibitor of checkpoint kinases Wee 1 and Chk1
CAS Number: 1177150-89-8
Molecular Weight: 346.3
Molecular Formula: C20H12N2O3•H20
* Refer to Certificate of Analysis for lot specific data (including water content).
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Wee 1/Chk1 Inhibitor is a potent inhibitor of checkpoint kinases Wee 1 and Chk1 (IC50 = 97 nM and 47 nM, respectively). The pyrrolocarbazole compound, Wee 1/Chk1 Inhibitor, inhibits these kinases in an ATP-competitive manner. Wee 1/Chk1 Inhibitor also inhibits Cdk4 and PKC.

Solubility :
Soluble in DMSO or Ethanol
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16760707
SMILES :
C1=CC=C(C=C1)C2=CC3=C(C4=C(N3)C=CC(=C4)O)C5=C2C(=O)NC5=O.O

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Certificate of Analysis

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