WAY 161503 hydrochlorideA potent SR-2C agonist

WAY 161503 hydrochloride (CAS 276695-22-8)

WAY 161503 hydrochloride | CAS 276695-22-8 is rated 5.0 out of 5 by 1.
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Synonym: 8,9-Dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one hydrochloride
Application: A potent SR-2C agonist
CAS Number: 276695-22-8
Purity: ≥98%
Molecular Weight: 308.59
Molecular Formula: C11H11Cl2N3O•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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WAY 161503 hydrochloride is a potent and selective SR-2C agonist (Ki = 4 nM; EC50 = 12 nM).


References

Rosenzweig-Lipson et al (2000) Antiobesity-like effects of the selective 5-HT2C agonist WAY 161503. FASEB J. 14 A1321. Welmaker et al (2000) Synthesis and 5-hydroxytryptamine (5-HT) activity of 2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5-(6H)ones and 2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoxalines. Bioorg.Med.Chem.Lett. 10 1991. Cryan and Lucki (2000) Antidepressant-like behavioral effects mediated by 5-hydroxytryptamine2C receptors. J.Pharmacol.Exp.Ther. 295 1120.

Physical State :
Solid
Solubility :
Soluble in water (25 mM), DMSO (100 mM), and ethanol (25 mM).
Storage :
Desiccate at room temperature
Refractive Index :
n20D 1.68 (Predicted)
IC50 :
SR-2C: EC5050 = 12 nM (human)
Ki Data :
SR-2C: Ki= 4 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
nwg
RTECS :
UQ4890017
PubChem CID :
21976692
MDL Number :
MFCD06411596
SMILES :
C1CN2C(CN1)C(=O)NC3=CC(=C(C=C32)Cl)Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Xie et al Xie et al. (PubMed ID 22906126) found that WAY 161503 regulated the inhibitory transmission in substantia gelatinosa (SG) via the activation of 5-HT receptor subtypes. -SCBT Publication Review
Date published: 2015-01-19
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