VU 1545 A positive allosteric modulator of mGluR-5

VU 1545  (CAS 890764-63-3)

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Application: A positive allosteric modulator of mGluR-5
CAS Number: 890764-63-3
Purity: >98%
Molecular Weight: 402.38
Molecular Formula: C22H15FN4O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
VU 1545 sc-204388 10 mg $155.00
VU 1545 sc-204388A 50 mg $660.00

VU 1545 is a positive allosteric modulator of metabotropic glutamate receptor type 5 (mGluR-5) (EC50 = 9.6 nM, Ki = 156 nM at rat mGluR-5).


References

de Paulis et al (2006) Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat cortical astrocytes. J.Med.Chem. 49 3332.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 nM).
Storage :
Store at 4° C
Boiling Point :
546.03° C at 760 mmHg (Predicted)
Density :
1.35 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
IC50 :
Metabotropic glutamate receptor 5: EC5050 = 9.6 nM (rat)
Ki Data :
Metabotropic glutamate receptor 5: Ki= 160 nM (rat)
pK Values :
pKa: 11.04 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
11625520
MDL Number :
MFCD12828761
SMILES :
C1=CC=C(C=C1)C2=NN(C(=C2)NC(=O)C3=CC=C(C=C3)[N+](=O)[O-])C4=CC=CC=C4F

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Certificate of Analysis

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