Voriconazole-d3 is a labeled form of Voriconazole which is an Ergosterol biosynthesis inhibitor. This monotriazole antifungal agent inhibits the growth of Candida, Cryptococcus, and Aspergillus species. Studies suggest that Voriconazole-d3 can be synthesized by modifying the structure of fluconazole. This antifungal agent functions by inhibiting cytochrome P450 dependent 14-α-sterol demethylase, which is responsible in the biosynthesis of Ergosterol. Furthermore, Voriconazole-d3 inhibits fungal growth, cell wall thinning, and cell membrane degradation.
1. Belanger, P., et al. 1997. Antimicrob. Agents Chemother. 41: 1840-1842. PMID: 9257776 2. Marco, F., et al. 1998. Antimicrob. Agents Chemother. 42: 161-163. PMID: 9449278 3. Espinel-Ingroff, A. 1998. J. Clin. Microbiol. 36: 198-202. PMID: 9431946
Soluble in Methanol
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
Various publications cite the use of VoriconazoleVarious publications cite the use of Voriconazole-d3, a labeled Ergosterol Biosynthesis inhibitor, for its inhibition of fungal growth and cell wall thinning/cell membrane degradation. -SCBT Publication Review
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