Voriconazole-d3

Voriconazole-d3 (CAS 137234-62-9 unlabeled)

Voriconazole-d3 | CAS 137234-62-9 (unlabeled) is rated 5.0 out of 5 by 1.
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Synonym: VRC-d3; Vfend-d3; Voriconazol-d3
Application: A labeled Ergosterol Biosynthesis inhibitor
CAS Number: 137234-62-9 unlabeled
Purity: ≥97% Isotopic Purity ≥99%
Molecular Weight: 352.33
Molecular Formula: C16H11D3F3N5O
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Voriconazole-d3 is a labeled form of Voriconazole which is an Ergosterol biosynthesis inhibitor. This monotriazole antifungal agent inhibits the growth of Candida, Cryptococcus, and Aspergillus species. Studies suggest that Voriconazole-d3 can be synthesized by modifying the structure of fluconazole. This antifungal agent functions by inhibiting cytochrome P450 dependent 14-α-sterol demethylase, which is responsible in the biosynthesis of Ergosterol. Furthermore, Voriconazole-d3 inhibits fungal growth, cell wall thinning, and cell membrane degradation.


References

1. Belanger, P., et al. 1997. Antimicrob. Agents Chemother. 41: 1840-1842. PMID: 9257776
2. Marco, F., et al. 1998. Antimicrob. Agents Chemother. 42: 161-163. PMID: 9449278
3. Espinel-Ingroff, A. 1998. J. Clin. Microbiol. 36: 198-202. PMID: 9431946

Physical State :
Solid
Solubility :
Soluble in Methanol
Storage :
Store at 4° C
Melting Point :
115-120° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Transport :
UN 2811, Class 6.1, Packing group III
PubChem CID :
46783259
SMILES :
[2H]C([2H])([2H])[C@@H](C1=NC=NC=C1F)[C@](CN2C=NC=N2)(C3=C(C=C(C=C3)F)F)O

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Certificate of Analysis

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Voriconazole-d3  Product Citations

See how others have used Voriconazole-d3. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 25999694  Chung, H. et al. 2015. Drug Des Devel Ther. 9: 2609-16.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Various publications cite the use of Voriconazole Various publications cite the use of Voriconazole-d3, a labeled Ergosterol Biosynthesis inhibitor, for its inhibition of fungal growth and cell wall thinning/cell membrane degradation. -SCBT Publication Review
Date published: 2015-07-20
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