Vinclozolin M2 A dicarboximide fungicide

Vinclozolin M2 (CAS 83792-61-4)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 55ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: 3',5'-Dichloro-2-hydroxy-2-methylbut-3-enanilide
Application: A dicarboximide fungicide
CAS Number: 83792-61-4
Molecular Weight: 260.12
Molecular Formula: C11H11Cl2NO2
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Vinclozolin M2 and M1 are metabolites of vinclozolin, a dicarboximide fungicide widely used in the United States and Europe for control of diseases caused by B. cineera, S. sclerotiorum, and Monilinia species in fruits, grapes, ornamental plants, turfgrass and vegetables. M1 and M2, are effective antagonists of the androgen receptor in rats exhibiting Ki values of 92 and 9.7 μM respectively. In fathead minnow, M1 and M2 failed to compete for high-affinity, low capacity testosterone binding sites in brain and ovary cytosolic fractions suggesting that they are not anti-androgens in this species.


References

1 Pothuluri, J.V., Freeman, J.P., Heinze, T.M., et al. Biotransformation of vinclozolin by the fungus Cunninghemella elegans. J Agric Food Chem 48 6138-6148 (2000). 2 Kelce, W.R., Monosson, E., Gamcsik, M.P., et al. Enviromental hormone disruptors: Evidence that vinclozolin developmental toxicity is mediated by antiandrogenic metabolites. Toxicol Appl Pharmacol 126 276-285 (1994). 3 Makynen, E.A., Kahl, M.D., Jensen, K.M., et al. Effects of the mammalian antiandrogen vinclozolin on development and reproduction of the fathead minnow. Aquatic Toxicology 48 461-475 (2000).

Physical State :
Solid
Solubility :
Soluble in ethanol (~30 mg/ml), DMSO (~30 mg/ml), DMF (~30 mg/ml), and 1:1 ethanol:PBS (pH 7.2) (~0.5 mg/ml).
Storage :
Store at -20° C
Melting Point :
161.32° C (Predicted)
Boiling Point :
426.91° C at 760 mmHg (Predicted)
Density :
1.38 g/cm3 (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
Ki Data :
Androgen receptor: Ki= 9.7 µM (rat)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
115209
MDL Number :
MFCD00871983
SMILES :
CC(C=C)(C(=O)NC1=CC(=CC(=C1)Cl)Cl)O

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 65ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 5ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.