Vinclozolin M2 A dicarboximide fungicide

Vinclozolin M2 (CAS 83792-61-4)

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Synonym: 3',5'-Dichloro-2-hydroxy-2-methylbut-3-enanilide
Application: A dicarboximide fungicide
CAS Number: 83792-61-4
Molecular Weight: 260.12
Molecular Formula: C11H11Cl2NO2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Vinclozolin M2 and M1 are metabolites of vinclozolin, a dicarboximide fungicide widely used in the United States and Europe for control of diseases caused by B. cineera, S. sclerotiorum, and Monilinia species in fruits, grapes, ornamental plants, turfgrass and vegetables. M1 and M2, are effective antagonists of the androgen receptor in rats exhibiting Ki values of 92 and 9.7 μM respectively. In fathead minnow, M1 and M2 failed to compete for high-affinity, low capacity testosterone binding sites in brain and ovary cytosolic fractions suggesting that they are not anti-androgens in this species.


1 Pothuluri, J.V., Freeman, J.P., Heinze, T.M., et al. Biotransformation of vinclozolin by the fungus Cunninghemella elegans. J Agric Food Chem 48 6138-6148 (2000). 2 Kelce, W.R., Monosson, E., Gamcsik, M.P., et al. Enviromental hormone disruptors: Evidence that vinclozolin developmental toxicity is mediated by antiandrogenic metabolites. Toxicol Appl Pharmacol 126 276-285 (1994). 3 Makynen, E.A., Kahl, M.D., Jensen, K.M., et al. Effects of the mammalian antiandrogen vinclozolin on development and reproduction of the fathead minnow. Aquatic Toxicology 48 461-475 (2000).

Physical State :
Solubility :
Soluble in ethanol (~30 mg/ml), DMSO (~30 mg/ml), DMF (~30 mg/ml), and 1:1 ethanol:PBS (pH 7.2) (~0.5 mg/ml).
Storage :
Store at -20° C
Melting Point :
161.32° C (Predicted)
Boiling Point :
426.91° C at 760 mmHg (Predicted)
Density :
1.38 g/cm3 (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
Ki Data :
Androgen receptor: Ki= 9.7 µM (rat)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :

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Certificate of Analysis

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