Vinblastine Sulfate An anti-mitotic agent which arrests the cell cycle in the G2/M-phase

Vinblastine Sulfate (CAS 143-67-9)

Vinblastine Sulfate | CAS 143-67-9 is rated 5.0 out of 5 by 1.
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Synonym: VLB; Vincaleukoblastine sulfate salt
Application: An anti-mitotic agent which arrests the cell cycle in the G2/M-phase
CAS Number: 143-67-9
Purity: ≥98%
Molecular Weight: 909.05
Molecular Formula: C46H58N4O9•H2SO4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Vinblastine Sulfate is an antineoplastic agent with anti-mitotic properties and immunosuppressive activity. Vinblastine sulfate depolymerizes microtubules by binding tubulin and inducing self-association in spiral aggregates. This reaction that appears to be regulated by the C-terminus of β-Tubulin and is enhanced by GDP and GTP. Vinblastine sulfate has been observed to arrest the cell cycle in the G2/M-phase by blocking mitotic spindle formation. Vinblastine sulfate has also been documented to trigger Raf-1 activation and phosphorylation of Bcl-2 family proteins, to induce p53 expression, and to induce apoptosis in several tumor cell lines. The compound has also acted as a substrate of PGP and CYP3A4.


References

1. Jordan, M.A., et al. 1985. Cancer Res. 45: 2741-2747. PMID: 3986806
2. Himes, R.H. 1991. Pharmacol. Ther. 51: 257-267. PMID: 1784631
3. Tsukidate, K., et al. 1993. Am. J. Pathol. 143: 918-925. PMID: 8362985
4. Panda, D., et al. 1996. J. Biol. Chem. 271: 29807-29812. PMID: 8939919
5. Rai, S.S. and Woolff, J. 1998. J. Biol. Chem. 273: 31131-31137. PMID: 9813016
6. Tashiro, E., et al. 1998. Jpn. J. Cancer Res. 89: 940-946. PMID: 9818030
7. Jordan, A., et al. 1998. Med Res Rev. 18: 259-296. PMID: 9664292
8. Jordan, M.A. and Wilson, L. 1998. Meth. Enzymol. 298: 252-276. PMID: 9751887
9. Rai, S.S., et al. 1998. Proc. Natl. Acad. Sci. U.S.A. 95: 4253-4257. PMID: 9539723
10. Chen, G.K., et al. 2000. Br. J. Cancer. 83: 892-898. PMID: 10970691

Physical State :
Solid
Solubility :
Soluble in water (10 mg/ml), DMSO (50 mg/ml), and methanol.
Storage :
Store at -20° C
Melting Point :
267° C (lit.)
Refractive Index :
n20D 1.67
Optical Activity :
α21/D -21.7°, c = 2 in methanol
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
YY8400000
PubChem CID :
241902
Merck Index :
14: 9982
MDL Number :
MFCD00082457
EC Number :
205-606-0
Beilstein Registry :
3659812
SMILES :
CC[C@@]1(C[C@@H]2C[C@@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O

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Vinblastine Sulfate  Product Citations

See how others have used Vinblastine Sulfate. Click on the entry to view the PubMed entry .

Citations 1 to 8 of 8 total

PMID: # 26674693  Negreira, N. et al. 2016. Sci. Total Environ. 544: 635-44.

PMID: # 24667756  Negreira, N. et al. 2014. The Science of the total environment. 482-483: 389-98.

PMID: # 24148406  2013. Talanta. 116: 290-9.

PMID: # 12364339  Junn, E. et al. 2002. J. Biol. Chem. 277: 47870-47877.

Matsumoto, F et al. 2000. Genetics and Molecular Biology. 23: 489-492.

PMID: # 1211375  Shiino, M. et al. 1975. Am. J. Anat. 144: 399-405.

Palevitz, B. et al. 1974. Chromosoma. 46: 327-341.

PMID: # 4341007  Prasad, KN. et al. 1972. Exp. Cell Res. 73: 436-440.

Citations 1 to 8 of 8 total

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. The compound, sc-201447, is provided as a white powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-18
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Rated 5 out of 5 by from Junn Junn, et. al. (PubMed ID 12364339) treated COS-7 cells with vinblastine sulfate, alongside proteasome inhibitors and found that MG-132-induced accumulation of Parkin as a singlelarge peri-nuclear aggresome was significantly abated. -SCBT Publication Review
Date published: 2015-05-02
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