Vildagliptin is a dipeptidyl peptidase-4 (CD26) inhibitor. CD26 activates serine proteases in immune/inflammatory cells. Vildagliptin also inhibits dipeptidyl-peptidase 8 (DPRP1) and dipeptidyl-peptidase 9 (DPRP2), which have been correlated to T cell activation and immune function, as well as diabetes and cancer regulation.
1. Ahrén, B. et al. 2004. J. Clin. Endocrinol. Metab. 89(5): 2078-2084. PMID: 15126524
2. Ahrén, B. et al. 2004. Diabetes Care. 27(12): 2874-2880. PMID: 15562200
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