Venturicidin B A potent inhibitor of mitochondrial ATP synthase complex acting on the F0 membrane sector

Venturicidin B (CAS 33538-72-6)

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Application: A potent inhibitor of mitochondrial ATP synthase complex acting on the F0 membrane sector
CAS Number: 33538-72-6
Purity: >95%
Molecular Weight: 706.9
Molecular Formula: C40H66O10
* Refer to Certificate of Analysis for lot specific data (including water content).
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Venturicidin B is an antibiotic that has been reported to be a potent inhibitor of the ATP5 (mitochondrial ATP synthase complex). This compound interferes with the F0 portion of membrane-located K+ and H+-ATPase channels and decreases probability of the channels from opening. By blocking proton transfer across the membrane, Venuricidin B causes a halt in ATP synthase activity.


References

1. Galanis, M., et al. 1989. FEBS Lett. 249: 333-336. PMID: 2661266
2. Matsuno-Yagi, A. and Hatefi, Y. 1993. J. Biol. Chem. 268: 6168-6173. PMID: 8454592
3. Miedema, H., et al. 1994. Biochem. Biophys. Res. Commun. 203: 1005-1012. PMID: 8093018

Appearance :
Lyophilized
Physical State :
Solid
Derived From :
Streptomyces sp.
Solubility :
Soluble in ethanol, methanol, DMF, DMSO, and water (poor).
Storage :
Store at 4° C
Melting Point :
145-149° C
Boiling Point :
823.39° C at 760 mmHg (Predicted)
Density :
1.14 g/cm3 (Predicted)
Refractive Index :
n20D 1.54 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6443772
MDL Number :
MFCD08061904
SMILES :
CCC(=O)C(C)C(C(C)CC(C)C1C(CC(C=CC(CCCC=C(C2C(=CCC(O2)(CC(=O)O1)O)C)C)OC3CC(C(C(O3)C)O)O)C)C)O

Download SDS (MSDS)

Certificate of Analysis

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