Venturicidin B is an antibiotic that has been reported to be a potent inhibitor of the ATP5 (mitochondrial ATP synthase complex). This compound interferes with the F0 portion of membrane-located K+ and H+-ATPase channels and decreases probability of the channels from opening. By blocking proton transfer across the membrane, Venuricidin B causes a halt in ATP synthase activity.
1. Galanis, M., et al. 1989. FEBS Lett. 249: 333-336. PMID: 2661266
2. Matsuno-Yagi, A. and Hatefi, Y. 1993. J. Biol. Chem. 268: 6168-6173. PMID: 8454592
3. Miedema, H., et al. 1994. Biochem. Biophys. Res. Commun. 203: 1005-1012. PMID: 8093018
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