Venturicidin A, an antibiotic and antifungal compound, has been noted to be a potential inhibitor of E. coli H+-ATPase. Experiments suggest that this compound strongly inhibits ATP-driven proton transport and ATP hydrolysis. More detailed studies show that Venturicidin A acts on the membrane sector F0. Purified bovine F0 has been reported to cause voltage sensitive K+ channels. Venturicidin A demonstrates the ability to drastically decrease the open probability of the channel. Venturicidin A is an inhibitor of ATP5.
1. Perlin, D.S., et al. 1985. Biochim. Biophys. Acta. 807: 238-244. PMID: 2859888
2. Matsuno-Yagi, A. and Hatefi, Y. 1993. J. Biol. Chem. 268: 6168-6173. PMID: 8454592
3. Miedema, H., et al. 1994. Biochem. Biophys. Res. Commun. 203: 1005-1012. PMID: 8093018
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