Venturicidin A An antibiotic and potent inhibitor of mitochondrial ATP synthase

Venturicidin A (CAS 33538-71-5)

Venturicidin A | CAS 33538-71-5 is rated 5.0 out of 5 by 1.
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Synonym: Aabomycin A1
Application: An antibiotic and potent inhibitor of mitochondrial ATP synthase
CAS Number: 33538-71-5
Purity: >95%
Molecular Weight: 750.0
Molecular Formula: C41H67NO11
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Venturicidin A, an antibiotic and antifungal compound, has been noted to be a potential inhibitor of E. coli H+-ATPase. Experiments suggest that this compound strongly inhibits ATP-driven proton transport and ATP hydrolysis. More detailed studies show that Venturicidin A acts on the membrane sector F0. Purified bovine F0 has been reported to cause voltage sensitive K+ channels. Venturicidin A demonstrates the ability to drastically decrease the open probability of the channel. Venturicidin A is an inhibitor of ATP5.


References

1. Perlin, D.S., et al. 1985. Biochim. Biophys. Acta. 807: 238-244. PMID: 2859888
2. Matsuno-Yagi, A. and Hatefi, Y. 1993. J. Biol. Chem. 268: 6168-6173. PMID: 8454592
3. Miedema, H., et al. 1994. Biochem. Biophys. Res. Commun. 203: 1005-1012. PMID: 8093018

Appearance :
Lyophilized
Physical State :
Solid
Derived From :
Streptomyces sp.
Solubility :
Soluble in ethanol, methanol, DMF, DMSO, and water (poor).
Storage :
Store at 4° C
Boiling Point :
874.86° C at 760 mmHg (Predicted)
Density :
1.17 g/cm3 (Predicted)
Refractive Index :
n20D 1.54 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
YX4556000
PubChem CID :
6438066
Merck Index :
14: 9947
MDL Number :
MFCD00036323
EC Number :
251-568-3
SMILES :
CCC(=O)[C@@H](C)[C@H]([C@H](C)CC(C)[C@@H]1[C@@H](C[C@H](/C=C\[C@@H](CCC/C=C(\[C@@H]2C(=CC[C@@](O2)(CC(=O)O1)O)C)/C)O[C@@H]3C[C@H]([C@@H]([C@H](O3)C)O)OC(=O)N)C)C)O

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Matsuno Matsuno-Yagi et al. (PubMed ID 8454592) showed that venturicidin A, when combined with organotin compounds, significantly decrease inhibition of the ATP synthase complex. -SCBT Publication Review
Date published: 2015-01-10
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