Vancomycin hydrochloride is a glycopeptide antibiotic that interferes with cell wall synthesis. Effective against Gram-positive bacteria.
For Vancomycin extracted from Streptomyces orientalis, please see sc-224363.
Intravitreal injection of vancomycin in experimental staphylococcal endophthalmitis: P. Homer, et al.; Acta Ophthalmol. (Copenh) 53, 311 (1975) Structure of vancomycin and its complex with acetyl-D-alanyl-D-alanine: G.M. Sheldrick, et al.; Nature 271, 223 (1978) Hydrophobic interactions affect hydrogen bond strengths in complexes between peptides and vancomycin or ristocetin: M.P. Williamson & D.H. Williams; Eur. J. Biochem. 138, 345 (1984)
Soluble in water (100 mg/ml), methanol, ethanol (<1 mg/ml at 25° C), and DMSO (<1 mg/ml at 25° C).
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HwangHwang, I. et al. (PubMed 25713030) reported that alteration of gut microbiota by Vancomycin and bacitracin (sc-252399) improves insulin resistance via glucagon-like peptide 1 in diet-induced obesity. -SCBT Publication Review
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