Validamycin A is an antibiotic fungicide that inhibits trehalase activity in plants, insects, and fungi and causes the accumulation of trehalose in transgenic plants. Validamycin A has also demonstrated antiviral activity against fungal plant pathogens, including Pellicularia sasakii and Rhizoctonia solani, but does not appear to be fungicidal in these cases.
Soluble in water, methanol, DMSO, DMF, ethanol (slightly), and acetone (slightly). Insoluble in ethyl acetate, and diethyl ether.
Desiccate at -20° C
813.66° C at 760 mmHg
α24/D +100°, c = 1 in water or pyridine; α24/D +92°, c = 1 in DMF
pKa: 12.92 (Predicted), pKb: 6.93 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
ZhouZhou, TC. Et al. (PubMed 25060680) demonstrated that amplification of the val gene cluster enhanced production of the antibiotic Validamycin A (Validamycin; Validacin; Valimon) by S. hygroscopicus 5008. -SCBT Publication Review
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