Usnic acid

Usnic acid (CAS 125-46-2)

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Synonym: Uanic acid; Usninic acid; Usnein
Application: An enzyme inhibiting antitumor agent
CAS Number: 125-46-2
Purity: ≥98%
Molecular Weight: 344.32
Molecular Formula: C18H16O7
* Refer to Certificate of Analysis for lot specific data (including water content).
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Usnic acid is an antimicrobial, antitumor enzyme inhibiting agent shown to uncouple oxidative phosphorylation in mouse-liver mitochondria. Usnic acid induces necrosis in certain cells.


References

1. Abo-Khatwa, A N., et al., 1996. Lichen acids as uncouplers of oxidative phosphorylation of mouse-liver mitochondria. Natural toxins. 4(2): 96-102. PMID: 8726330
2. Han, Derick., et al., 2004. Usnic acid-induced necrosis of cultured mouse hepatocytes: inhibition of mitochondrial function and oxidative stress. Biochemical pharmacology. 67(3): 439-51. PMID: 15037196

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (<0.11 g/100ml), acetone (0.77 g/100ml), ethyl acetate (0.88 g/100ml), fural (7.32 g/100ml), and furfuryl alcohol (1.21 g/100ml).
Storage :
Store at room temperature
Melting Point :
204° C
Boiling Point :
~594.8° C at 760 mmHg (Predicted)
Density :
~1.50 g/cm3 (Predicted)
Refractive Index :
n20D 1.64 (Predicted)
Optical Activity :
α20/D +495.0°±10.0°, c = 0.7 in chloroform
pK Values :
pKa: 4 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
HP5270000
PubChem CID :
5646
Merck Index :
14: 9893
MDL Number :
MFCD00065294
EC Number :
204-704-7
SMILES :
CC1=C(C(=C2C(=C1O)C3(C(=CC(=O)C(C3=O)C(=O)C)O2)C)C(=O)C)O

Download SDS (MSDS)

Certificate of Analysis

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