|PRODUCT NAME||CATALOG #||UNIT||PRICE||QTY||FAVORITES|
|Ubiquitin Isopeptidase Inhibitor I, G5||sc-356181||10 mg||$240.00||
Ubiquitin Isopeptidase Inhibitor I, G5 is a cell-permeable cross-conjugated α,β-unsaturated dienone compound reported to induce caspase activation and apoptosis via the apoptosome-independent mitochondrial pathway by selectively inhibiting ubiquitin isopeptidase activity. The cellular expression of Bax and Bak is essential for G5-activated apoptosis, while Bcl-2 appears to protect cells against the effect of G5. G5 is reported to exhibit similar pharmacological effects as Ubiquitin Isopeptidase Inhibitor II, F6 but is reported to be more potent (sc-296678). Additionally, at higher concentrations, it has been shown to induce necrosis in apoptosis-resistant MEFs-DKO.
1. Aleo, E., et al. 2006. Cancer Res. 66: 9235-9244. PMID: 16982768
2. Fontanini, A., et al. 2009. J. Biol. Chem. 284: 8369-8381. PMID: 19139105
See how others have used Ubiquitin Isopeptidase Inhibitor I, G5. Click on the entry to view the PubMed entry .
PMID: # 24985478
Rush, J.S. et al. 2014. Antagonizing c-Cbl enhances EGFR-dependent corneal epithelial homeostasis. Investigative ophthalmology & visual science. 55: 4691-9.
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