U 82836E is a free radical scavenger and antioxidant which becomes cytotoxic at higher concentrations. It is a second-generation lazaroid inhibitor of iron-dependent lipid peroxidation in rat brain cells (IC50 = 0.6 µM). U 82836E shows neuroprotective activity in a mouse head injury model (MHI) and causes a reduction in cyanide-induced cell death in rat cortical neurons. At higher concentrations, however, U 82836E has been shown to reduce the viability of rat brain endothelial cells (RBE4, IC50 = 0.032 mM).
1. Jacobsen, E J., et al., 1992. 2-(Aminomethyl)chromans that inhibit iron-dependent lipid peroxidation and protect against central nervous system trauma and ischemia. Journal of medicinal chemistry. 35(23): 4464-72. PMID: 1447746
2. Altavilla, D., et al., 1998. Inhibition of tumour necrosis factor and reversal of endotoxin-induced shock by U-83836E, a 'second generation' lazaroid in rats. British journal of pharmacology. 124(6): 1293-9. PMID: 9720803
3. Vignes, J R., et al., 2006. In vitro efficacy of three lazaroids in a model of acute chemical neuronal hypoxia. Neuroscience letters. 407(2): 171-5. PMID: 16973271
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