U-75302 A selective leukotriene B4 antagonist

U-75302 (CAS 119477-85-9)

U-75302 | CAS 119477-85-9 is rated 5.0 out of 5 by 1.
  • y_2019, m_6, d_24, h_24
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_201331, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 73ms
  • REVIEWS, PRODUCT
Application: A selective leukotriene B4 antagonist
CAS Number: 119477-85-9
Purity: ≥98%
Molecular Weight: 361.5
Molecular Formula: C22H35NO3
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

U-75302 is a selective P2Y7 (leukotriene B4 BLT1) antagonist, Ki=159 nM for inhibition of [3H]-LTB4 binding to guinea pig lung membranes.


References

1: A.H. Lin et al. Ann. NY Acad. Sci. 1988 524 196 2: R.C. Falcone and D. Aharony J. Pharmacol. Exp. Ther. 1990 255 565

Appearance :
Oil
Physical State :
Liquid
Solubility :
Soluble in DMSO (10 mg/ml), and ethanol (25 mg/ml).
Storage :
Store at -80° C
Melting Point :
~208.53° C (Predicted)
Boiling Point :
505.21° C (Predicted)
Refractive Index :
n20D 1.56
Ki Data :
LTB4: Ki= 159 nM; LTB4: Ki= 700 nM
Fluoresence :
λex 463 nm λem 490 nm in ethanol
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
14015196
MDL Number :
MFCD00270915
SMILES :
CCCCCC=CCC(C=CC1=NC(=CC=C1)CC(CCCCO)O)O

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

U-75302  Product Citations

See how others have used U-75302. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 25554564  Capannolo, M. et al. 2015. Eur Neuropsychopharmacol. 25: 413-24.

PMID: # 10934230  Yokomizo, T. et al. 2000. J. Exp. Med. 192: 421-432.

Citations 1 to 2 of 2 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 53ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Yokomizo et al Yokomizo et al. (PubMed ID 10934230) used U-75302, a BLT2 antagonist, as a negative control to study LTB4 inhibition, as it failed to inhibit LTB4. BLT2. -SCBT Publication Review
Date published: 2015-04-08
  • y_2019, m_6, d_24, h_24
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_201331, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 4ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.