Tyrphostin AG 99 is a potent, cell-permeable, reversible inhibitor of EGFR (epidermal growth factor receptor) and EGF-dependent cell proliferation. Stimulation of EGFRs result in tumor growth and proliferation, inhibition of apoptosis, stimulation of angiogenesis and the promotion of tissue invasion and metastasis. Tyrphostin AG 99 has been shown to inhibit EGFR phosphorylation and ERK1 and ERK2 activities.
1. Gazit, A., et al. 1989. J. Med. Chem. 32: 2344-2352. PMID: 2552117 2. Gazit, A., et al. 1991. J. Med. Chem. 34: 1896-1907. PMID: 1676428 3. Martin, B.L. 1998. Biochem. Pharmacol. 56: 483-488. PMID: 9763224 4. Pai, R., et al. 1998. Gastroenterology. 114: 706-713. PMID: 9516391 5. Ancha, H.R., et al. 2006. Dig. Dis. Sci. 51: 274-281. PMID: 16534669
Soluble in DMSO (100 mM), ethanol (5 mM), DMF (~20 mg/ml), and 1:1 solution of DMSO:PBS (pH 7.2) us (~0.5 mg/ml). Insoluble in water.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Pai et alPai et al. (PubMed ID 9516391) found that Tyrphostin AG 99 significantly inhibited ulcer healing and reduced EGF-R levels, EGF-R phosphorylation, and ERK1 and ERK2 activity in rats. -SCBT Publication Review
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