Tyrphostin AG 112 An EGFR inhibitor

Tyrphostin AG 112 (CAS 144978-82-5)

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Synonym: Tyrphostin A48; 3-Amino-2,4-dicyano-5-(4'-hydroxyphenyl)penta-2,4-dienonitrile
Application: An EGFR inhibitor
CAS Number: 144978-82-5
Molecular Weight: 236.23
Molecular Formula: C13H8N4O
* Refer to Certificate of Analysis for lot specific data (including water content).
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Tyrphostin AG 112 is an inhibitor of the epidermal growth factor receptor (EGFR).


References

1. Gazit, A., et al., 1989. Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. Journal of medicinal chemistry. 32(10): 2344-52. PMID: 2552117

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml), and ethanol (1 mg/ml).
Storage :
Store at -20° C
Melting Point :
228-229° C
Boiling Point :
642.03° C at 760 mmHg (Predicted)
Density :
1.38 g/cm3 (Predicted)
Refractive Index :
n20D 1.69 (Predicted)
IC50 :
EGFR: IC50 = 100 nM (human); EGFR: IC50 = 125 nM; Plasmodium falciparum: IC50 = 12.59 µM
pK Values :
pKa: 8.99 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
5328804
MDL Number :
MFCD00236447
SMILES :
C1=CC(=CC=C1/C=C(\\C#N)/C(=C(C#N)C#N)N)O

Download SDS (MSDS)

Certificate of Analysis

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