Tunicamycin A competitive cell cycle inhibitor exhibiting antiungal properties

Tunicamycin (CAS 11089-65-9)

Tunicamycin | CAS 11089-65-9 is rated 4.5 out of 5 by 2.
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Application: A competitive cell cycle inhibitor exhibiting antiungal properties
CAS Number: 11089-65-9
Purity: ≥99% (total complex)
Molecular Weight: 840.0 (Avg.)
Molecular Formula: C38H62N4O16 (Tun B)
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Tunicamycin is a mixture of Tunicamycins A, B, C and D which has been widely used in the study of glycoprotein synthesis in various biological systems. Tunicamycin inhibits GNPTAB (GlcNAc phosphotransferase, GPT) and inhibts the formation of N-glycosidic linkages in glycoprotein synthesis. Tunicamycin has also been reported to have a dose-dependent inhibition of DNA synthesis, to inhibit protein glycosylation, to suppress the S-phase of the cell cycle, and to arrest the cell cycle in late G1. As a member of a family of antibiotics produced by Streptomyces lysosuperficus, this compound is noted to be active in vitro against gram-positive bacteria, fungi, yeasts and viruses. During protein glycosylation, tunicamycin is noted to be an inhibitor of the transfer of saccharide moieties to dolichol during dolichol-linked glycoprotein synthesis. Dose-dependent inhibition of DNA synthesis may be related to the alteration of glycoproteins, which thereby affects the transport of thymidine into cells. Additionally, tunicamycin has been reported to prevent cell cycle progression in primary cultures of rat glial cells, as well as inhibit lipid-mediated protein glycosylation in chick or mouse fibroblasts in a dose-dependent manner.


References

1. Duksin, D., et al. 1982. J. Biol. Chem. 257: 3105-3109. PMID: 7061468
2. Langan, T.J. and Slater, M.C. 1991. J. Cell Physiol. 149: 284-292. PMID: 1748720
3: Ishii, S. and Volpe, J.J. 1987. J. Neurochem 49: 1606-1612. PMID: 3668542

Physical State :
Solid
Derived From :
Streptomyces sp.
Solubility :
Soluble in water (partly miscible), alkaline water, pyridine, hot methanol, DMSO (>10 mg/ml), ethanol (5 mg/ml), butanol (slightly), and DMF. Insoluble in acetone, ethyl acetate, chloroform, benzene, and acidic water.
Storage :
Store at room temperature
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
YO7980200
Merck Index :
14: 9819
MDL Number :
MFCD00065709
Beilstein Registry :
6888090

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Certificate of Analysis

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Tunicamycin  Product Citations

See how others have used Tunicamycin. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 30 total

PMID: # 28536105  Ramírez-Peinado, S. et al. 2017. J. Cell. Sci. 130: 2251-2265.

PMID: # 29118074  Baumann, J. et al. 2017. Mol. Biol. Cell.

PMID: # 28981087  van Raam, BJ. et al. 2017. Cell Death Dis. 8: e3069.

PMID: # 29074567  Gendarme, M. et al. 2017. Mol. Biol. Cell.

PMID: # 28953979  English, BC. et al. 2017. PLoS Pathog. 13: e1006589.

PMID: # 26040720  Khaminets, A. et al. 2015. Nature. 522: 354-8.

PMID: # 25903460  Kim, AY. et al. 2015. BMC Genomics. 16: 338.

PMID: # 25824232  Li, R. et al. 2015. Antimicrob. Agents Chemother. 59: 3460-8.

PMID: # 26040720  Khaminets, A. et al. 2015. Nature. 522: 354-8.

PMID: # 26231208  Vaughn, LS. et al. 2015. J. Biol. Chem. 290: 22543-57.

Citations 1 to 10 of 30 total

Why is tunicamycin insoluble in water?

Asked by: rachel220
Thank you for your question. This biochemical is soluble in water (partly miscible), alkaline water, pyridine, hot methanol, DMSO (>10 mg/ml), ethanol (5 mg/ml), butanol (slightly), and DMF. Insoluble in acetone, ethyl acetate, chloroform, benzene, and acidic water. Please contact your local distributor or technical service for further assistance.
Answered by: Tech Service
Date published: 2019-03-25

What is a differences between Tunicamycin A, B,C,D?

Asked by: r7r sh
Thank you for the question. Tunicamycin is not a single compound but a mixture of homologous antibiotics. Our product was derived from Streptomyces sp. and it contains a mixture of Tunicamycin A, B,C and D. Tunicamycin A, B,C,D are homologs varying in the length of the carbon chain: Tunicamycin A = 8C, Tunicamycin B = 9C, Tunicamycin C = 10C and Tunicamycin D = 11C.
Answered by: Technical Support Europe
Date published: 2017-12-03

How should this be stored once dissolved in DMSO?

Asked by: SCM4
Because we do not have storage information once dissolved in DMSO, we do not recommending storing this product in DMSO. However, typically for long term storage in DMSO, other compounds are aliquoted and stored at -20 ºC to -80 ºC for 3-4 months in order to avoid repeated freeze/thaw cycles.
Answered by: Tech Service 11
Date published: 2017-03-17
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Rated 4 out of 5 by from Good product This chemical works well in primary neuronal culture system
Date published: 2018-10-03
Rated 5 out of 5 by from Ren et Ren et. al. (PubMed ID 19276076) used tunimycin to initiate endoplasmic reticulum stress. -SCBT Publication Review
Date published: 2015-04-13
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