Tubacin is a selective inhibitor of HDAC6 via inhibition of the second deacetylase domain (DD2). Tubacin does not inhibit HDAC6 histone deacetylase activity. Instead, it reversibly inhibits α-tubulin deacetylation. Tubacin increases α-tubulin acetylation levels with no effect on histone acetylation or cell cycle progression.
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YuanYuan, L. et al. (PubMed 25976407) observed that inhibiting the activity of HDAC6 with Tubacin, a specific HDAC6 inhibitor, reduced the oxygen-glucose deprivation (OGD)-induced necroptosis of cultured rat cortical neurons. In addition, inhibiting the activity of HDAC6 reversed the OGD-induced increase of reactive oxygen species (ROS) and the OGD-induced decrease of acetylated tubulin in the cultured rat cortical neurons. -SCBT Publication Review
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