TTNPB A synthetic stilbene analog of retinoic acid (RA) that acts as a potent retinoic acid receptor (RAR) agonist

TTNPB (CAS 71441-28-6)

TTNPB | CAS 71441-28-6 is rated 5.0 out of 5 by 1.
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Synonym: Arotinoic acid
Application: A synthetic stilbene analog of retinoic acid (RA) that acts as a potent retinoic acid receptor (RAR) agonist
CAS Number: 71441-28-6
Molecular Weight: 348.48
Molecular Formula: C24H28O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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TTNPB (4-[(E)-2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]benzoic Acid) is a synthetic stilbene analog of retinoic acid that acts as a potent retinoic acid receptor (RAR) agonist (EC50 = 21 nM, 4.0 nM, and 2.4 nM for RARα, RARβ, and RARγ, respectively).


References

Standeven, A.M., et al. 1996. Toxicol. Appl. Pharmacol. 138, 169. Beard, R.L., et al. 1995. J. Med. Chem. 38, 2820. R: 36/37/38-60-61; S: 26-36/37/39-45

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in DMSO (10 mM).
Storage :
Desiccate at -20° C
Melting Point :
240-241° C
Boiling Point :
486.8° C
Density :
1.06 g/cm3
Refractive Index :
n20D 1.58 (Predicted)
IC50 :
RARa: EC5050 = 21 nM; RARb: EC5050 = 4.0 nM; RARg: EC5050 = 2.4 nM
Ki Data :
Retinoic acid receptor beta: Ki= 0.5 nM (Homo sapiens); Retinoic acid receptor alpha: Ki= 21 nM (Homo sapiens); Retinoic acid receptor beta: Ki= 5 nM (Homo sapiens); Retinoic acid receptor gamma: Ki= 5 nM (Homo sapiens)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
DH6834900
PubChem CID :
5289501
MDL Number :
MFCD00673917
SMILES :
C/C(=C\\C1=CC=C(C=C1)C(=O)O)/C2=CC3=C(C=C2)C(CCC3(C)C)(C)C

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Certificate of Analysis

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TTNPB  Product Citations

See how others have used TTNPB. Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 25665923  Toyoda, T. et al. 2015. Stem Cell Res. 14: 185-97.

PMID: # 24454758  Araoka, T. et al. 2014. PLoS ONE. 9: e84881.

PMID: # 21519922  Zhang, Y. et al. 2011. Mol. Cell. Biochem. 355: 1-8.

PMID: # 21316346  Li, R. et al. 2011. Biochem. Biophys. Res. Commun. 406: 268-272.

PMID: # 17306764  Zou, F. et al. 2007. Biochem. Biophys. Res. Commun. 355: 494-500.

Citations 1 to 5 of 5 total
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Rated 5 out of 5 by from Araoka et al Araoka et al. (PubMed ID 24454758) found that the retinoid, TTNPB, was a potent intermediate mesoderm inducer in human iPSCs. -SCBT Publication Review
Date published: 2015-05-07
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